Hepatitis A: Detection by Immune Electron Microscopy of a Viruslike Antigen Associated with Acute Illness

Overview

Journal Science

Specialty Science

Date 1973 Dec 7

PMID 4356028

Citations 176

Authors

S M Feinstone

A Z Kapikian

R H Purceli

Affiliations

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Abstract

Spherical 27-nanometer particles were visualized in stools obtained from hepatitis A patients in the acute phase of the disease. The particle was serologically specific for this disease, and every hepatitis A patient tested demonstrated a serologic response to this antigen. The findings suggest that it is the etiologic agent of hepatitis A.

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