Stimulation of Brain Na+, K+-ATPase by Norepinephrine in Vivo: Prevention by Receptor Antagonists and Enhancement by Repeated Stimulation

Overview

Journal Brain Res

Specialty Neurology

Date 1983 Feb 7

PMID 6299462

Citations 6

Authors

A C Swann

Affiliations

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Abstract

The role of alpha 1- and beta-noradrenergic receptors in the stimulation of the K+-p-nitrophenylphosphatase activity and ouabain binding associated with rat brain Na+, K+-ATPase by acute or repeated yohimbine were examined. Repeated yohimbine increased enzyme activity and ouabain binding by about 25%; this was prevented by the alpha 1-receptor antagonist prazosin and decreased by the beta-antagonist propranolol. Pretreatment with repeated yohimbine increased the stimulation of enzyme activity by acute yohimbine while the stimulation was prevented by prazosin pretreatment.

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