Susceptibility of Neisseria Gonorrhoeae to Cefotaxime: in Vitro Studies and Treatment Results

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1982 Jan 1

PMID 6299208

Citations 2

Authors

U Neubert

H C Korting

G Ruckdeschel

Affiliations

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Abstract

More and more beta-lactamase-producing, penicillin-resistant strains of Neisseria gonorrhoeae are nowadays isolated in most parts of the world including the European continent. Therefore, there is a need for reliable alternatives in the treatment of gonorrhoea. Cefotaxime--first representative of a new generation of beta-lactamase-resistant cephalosporins--was evaluated for this reason, first in vitro and then in vivo. All 191 strains tested proved susceptible, the highest MIC amounting to 0.03 microgram/ml, a drug concentration well exceeded in plasma for more than 4 h after i.m. application of 0.5 g cefotaxime. In contrast to other investigators we have therefore decided to test this relatively small dose clinically without the addition of probenecid. The clinical results were excellent: 146 of 151 patients (96.7%) were cured. In the female sub-group (34 patients) the cure rate amounted to 100%. Thus, the i.m. injection of 0.5 g cefotaxime as a single dose must be looked upon as a reliable regimen for the cure of uncomplicated gonorrhoea, both in males and females.

Citing Articles

Recognition and clinical significance of mechanisms of bacterial resistance to beta-lactams.

Mouton R Antonie Van Leeuwenhoek. 1984; 50(5-6):711-27.

PMID: 6442123 DOI: 10.1007/BF02386236.

Cefodizime in serum and skin blister fluid after single intravenous and intramuscular doses in healthy volunteers.

Korting H, Schafer-Korting M, Maass L, Klesel N, Mutschler E Antimicrob Agents Chemother. 1987; 31(11):1822-5.

PMID: 3435129 PMC: 175046. DOI: 10.1128/AAC.31.11.1822.

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