Polymorphism of Genomic RNAs Within Rotavirus Serotypes and Subgroups

Overview

Journal Arch Virol

Specialty Microbiology

Date 1982 Jan 1

PMID 6297431

Citations 35

Authors

G M Beards

Affiliations

Soon will be listed here.

Abstract

The genome of human rotaviruses is composed of 11 segments of double stranded RNA. Analysis by polyacrylamide gel electrophoresis of the genomic RNA from a number of strains of the same serotype has demonstrated a significant polymorphism in the migration pattern. However, two strains differing from each other in serotype were found to have apparently identical RNA migration patterns. It is concluded that serotype cannot be deduced from RNA migration patterns. Degrees of polymorphism have been observed within each of three known human rotavirus serotypes.

Citing Articles

Sequential variation in genomic RNA patterns of human rotaviruses isolated from infantile gastroenteritis.

Buesa F, Duato M, Gimeno C, de Lomas J Ann Inst Pasteur Virol. 2020; 138(3):307-314.

PMID: 32288185 PMC: 7135673. DOI: 10.1016/S0769-2617(87)80017-5.

Molecular epidemiology of group A human rotaviruses in North West region, Cameroon.

Mbuh F, Armah G, Omilabu S, Ahmad A, Umoh J Pan Afr Med J. 2012; 12:108.

PMID: 23133708 PMC: 3489391.

Molecular characterization of rotavirus in Ireland: detection of novel strains circulating in the population.

OHalloran F, Lynch M, Cryan B, OShea H, Fanning S J Clin Microbiol. 2000; 38(9):3370-4.

PMID: 10970385 PMC: 87388. DOI: 10.1128/JCM.38.9.3370-3374.2000.

Electropherotypes and serotypes of human rotavirus in Estonia in 1989-1992.

Ginevskaya V, Amitina N, Eremeeva T, SHIRMAN G, Priimagi L, Drozdov S Arch Virol. 1994; 137(1-2):199-207.

PMID: 7979994 DOI: 10.1007/BF01311188.

Rotavirus serotypes and electropherotypes in Finland from 1986 to 1990.

Maunula L, von Bonsdorff C Arch Virol. 1995; 140(5):877-90.

PMID: 7605200 DOI: 10.1007/BF01314964.

References

Kapikian A, Cline W, Kim H, Kalica A, Wyatt R, VanKirk D . Antigenic relationships among five reovirus-like (RVL) agents by complement fixation (CF) and development of new substitute CF antigens for the human RVL agent of infantile gastroenteritis. Proc Soc Exp Biol Med. 1976; 152(4):535-9. DOI: 10.3181/00379727-152-39434. View

Espejo R, Avendano L, Munoz O, Romero P, Eternod J, Lopez S . Comparison of human rotaviruses isolated in Mexico City and in Santiago, Chile, by electrophoretic migration of their double-stranded ribonucleic acid genome segments. Infect Immun. 1980; 30(2):342-8. PMC: 551316. DOI: 10.1128/iai.30.2.342-348.1980. View

Kalica A, Greenberg H, Espejo R, Flores J, Wyatt R, Kapikian A . Distinctive ribonucleic acid patterns of human rotavirus subgroups 1 and 2. Infect Immun. 1981; 33(3):958-61. PMC: 350805. DOI: 10.1128/iai.33.3.958-961.1981. View

Bridger J . Location of type-specific antigens in calf rotaviruses. J Clin Microbiol. 1978; 8(6):625-8. PMC: 275314. DOI: 10.1128/jcm.8.6.625-628.1978. View

Rodger S, Bishop R, Birch C, McLean B, HOLMES I . Molecular epidemiology of human rotaviruses in Melbourne, Australia, from 1973 to 1979, as determined by electrophoresis of genome ribonucleic acid. J Clin Microbiol. 1981; 13(2):272-8. PMC: 273776. DOI: 10.1128/jcm.13.2.272-278.1981. View

Kapikian A, Cline W, Greenberg H, Wyatt R, Kalica A, Banks C . Antigenic characterization of human and animal rotaviruses by immune adherence hemagglutination assay (IAHA): evidence for distinctness of IAHA and neutralization antigens. Infect Immun. 1981; 33(2):415-25. PMC: 350714. DOI: 10.1128/iai.33.2.415-425.1981. View

Clarke I, McCrae M . Structural analysis of electrophoretic variation in the genome profiles of rotavirus field isolates. Infect Immun. 1982; 36(2):492-7. PMC: 351254. DOI: 10.1128/iai.36.2.492-497.1982. View

Sato K, Inaba Y, Miura Y, Tokuhisa S, MATUMOTO M . Antigenic relationships between rotaviruses from different species as studied by neutralization and immunofluorescence. Arch Virol. 1982; 73(1):45-50. DOI: 10.1007/BF01341726. View

Kalica A, Purcell R, Sereno M, Wyatt R, Kim H, Chanock R . A microtiter solid phase radioimmunoassay for detection of the human reovirus-like agent in stools. J Immunol. 1977; 118(4):1275-9. View

10.

Thouless M, Beards G, Flewett T . Serotyping and subgrouping of rotavirus strains by the ELISA test. Arch Virol. 1982; 73(3-4):219-30. DOI: 10.1007/BF01318076. View

11.

Beards G, PILFOLD J, Thouless M, Flewett T . Rotavirus serotypes by serum neutralisation. J Med Virol. 1980; 5(3):231-7. DOI: 10.1002/jmv.1890050307. View

12.

Wyatt R, Greenberg H, James W, Pittman A, Kalica A, Flores J . Definition of human rotavirus serotypes by plaque reduction assay. Infect Immun. 1982; 37(1):110-5. PMC: 347497. DOI: 10.1128/iai.37.1.110-115.1982. View

13.

BRANDT C, Kim H, Rodriguez W, Thomas L, Yolken R, Arrobio J . Comparison of direct electron microscopy, immune electron microscopy, and rotavirus enzyme-linked immunosorbent assay for detection of gastroenteritis viruses in children. J Clin Microbiol. 1981; 13(5):976-81. PMC: 273926. DOI: 10.1128/jcm.13.5.976-981.1981. View

14.

Thouless M, Bryden A, Flewett T, Woode G, Bridger J, Snodgrass D . Serological relationships between rotaviruses from different species as studied by complement fixation and neutralization. Arch Virol. 1977; 53(4):287-94. DOI: 10.1007/BF01315627. View