Synergism Among BIOLF-62, Phosphonoformate, and Other Antiherpetic Compounds

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1982 Dec 1

PMID 6297382

Citations 5

Authors

K O Smith

K S Galloway

K K Ogilvie

U O Cheriyan

Affiliations

Soon will be listed here.

Abstract

9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1 and 2 in vitro. Acycloguanosine did not show significant synergism with these two compounds. Bromovinyldeoxyuridine and phosphonoformate were highly synergistic against herpes simplex virus type 2, but not against type 1.

Citing Articles

Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

Crumpacker C, Kowalsky P, Oliver S, Schnipper L, Field A Proc Natl Acad Sci U S A. 1984; 81(5):1556-60.

PMID: 6324203 PMC: 344876. DOI: 10.1073/pnas.81.5.1556.

Mutually exclusive inhibition of herpesvirus DNA polymerase by aphidicolin, phosphonoformate, and acyclic nucleoside triphosphates.

Frank K, Cheng Y Antimicrob Agents Chemother. 1985; 27(4):445-8.

PMID: 2988429 PMC: 180071. DOI: 10.1128/AAC.27.4.445.

Toxicity of intravitreal injection of foscarnet in the rabbit eye.

She S, Peyman G, Schulman J Int Ophthalmol. 1988; 12(2):151-4.

PMID: 2976408 DOI: 10.1007/BF00137142.

Synergistic therapy by acyclovir and A1110U for mice orofacially infected with herpes simplex viruses.

ELLIS M, Lobe D, Spector T Antimicrob Agents Chemother. 1989; 33(10):1691-6.

PMID: 2556074 PMC: 172739. DOI: 10.1128/AAC.33.10.1691.

Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections.

Faulds D, Heel R Drugs. 1990; 39(4):597-638.

PMID: 2161731 DOI: 10.2165/00003495-199039040-00008.

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