Hair As a Biopsy Material. V. Hair Metal As an Index of Hepatic Metal in Rats: Copper and Zinc

Overview

Journal Am J Clin Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 1978 Mar 1

PMID 629220

Citations 4

Authors

R A Jacob

L M Klevay

G M Logan Jr

Affiliations

Soon will be listed here.

Abstract

Hair copper in 500 day-old adult rats was found to correlate directly with copper in whole liver (P less than 0.001) and the subcellular liver nuclear (P less than 0.022), and cytosol fractions (P less than 0.001). An inverse correlation was found between copper in liver microsomes and plasma cholesterol (P less than 0.044). Similar data analysis for zinc showed no significant correlations (P greater than 0.05). The determination of copper in hair may be useful for assessing total liver copper content in human beings. Copper in liver microsomes may participate in the control of plasma cholesterol.

Citing Articles

Copper, manganese, zinc, and cadmium in tissues from New Zealanders.

Casey C, Guthrie B, Robinson M Biol Trace Elem Res. 2013; 4(2-3):105-15.

PMID: 24271983 DOI: 10.1007/BF02783251.

Magnesium, calcium, copper, and zinc in meals : Correlations related to the epidemiology of ischemic heart disease.

Klevay L Biol Trace Elem Res. 2013; 4(2-3):95-104.

PMID: 24271982 DOI: 10.1007/BF02783250.

Hair analysis--a critical review.

Manson P, Zlotkin S Can Med Assoc J. 1985; 133(3):186-8.

PMID: 3893667 PMC: 1346144.

Dietary cholesterol lowers liver copper in rabbits.

Klevay L Biol Trace Elem Res. 1988; 16(1):51-7.

PMID: 2484535 DOI: 10.1007/BF02795333.