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Comparison of the Nucleotide Sequence of Cloned Human and Guinea-pig Pre-alpha-lactalbumin CDNA with That of Chick Pre-lysozyme CDNA Suggests Evolution from a Common Ancestral Gene

Overview
Specialty Biochemistry
Date 1982 Jun 11
PMID 6285305
Citations 23
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Abstract

Nucleotide sequence analyses of essentially full-length copies of human and guinea-pig pre-alpha-lactalbumin cDNAs contained within recombinant plasmids, (i) confirm the presence of 19 amino acid hydrophobic amino terminal peptide extensions encoded within each mRNA; and (ii) provides evidence for the existence of a minor variant of guinea-pig alpha-lactalbumin mRNA encoding a protein with a 36 residue carboxyl-terminal extension. Comparison of the nucleotide sequence within the coding region of the human, and the predominant guinea-pig pre-alpha-lactalbumin mRNAs, with the analogous region of hen pre-lysozyme mRNA provides compelling evidence that all have evolved from a common ancestral gene.

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References
1.
Brodbeck U, EBNER K . Resolution of a soluble lactose synthetase into two protein components and solubilization of microsomal lactose synthetase. J Biol Chem. 1966; 241(3):762-4. View

2.
Brew K, Vanaman T, Hill R . Comparison of the amino acid sequence of bovine alpha-lactalbumin and hens egg white lysozyme. J Biol Chem. 1967; 242(16):3747-9. View

3.
Brew K, Vanaman T, Hill R . The role of alpha-lactalbumin and the A protein in lactose synthetase: a unique mechanism for the control of a biological reaction. Proc Natl Acad Sci U S A. 1968; 59(2):491-7. PMC: 224699. DOI: 10.1073/pnas.59.2.491. View

4.
Brew K, Castellino F, Vanaman T, Hill R . The complete amino acid sequence of bovine alpha-lactalbumin. J Biol Chem. 1970; 245(17):4570-82. View

5.
Canfield R, Kammerman S, Sobel J, Morgan F . Primary structure of lysozymes from man and goose. Nat New Biol. 1971; 232(27):16-7. DOI: 10.1038/newbio232016a0. View