Interaction Between Mianserin and Clonidine at Alpha 2-adrenoceptors

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1982 Mar 1

PMID 6281667

Citations 1

Authors

Y Pommier

M Andrejak

P MOUILLE

H Dabire

B Lucet

H Schmitt

Affiliations

Soon will be listed here.

Abstract

The purpose of the present study was to characterize the effects of mianserin at alpha 2-adrenoceptors. Firstly, the action of mianserin on postganglionic sympathetic fibres has been studied using the tachycardia induced by stimulation of the cardiac nerve in dogs. Mianserin increased this tachycardia, but could not prevent the inhibitory effect of clonidine in this model. However, an antagonistic effect of mianserin against clonidine was observed when animals were pretreated with desipramine. Secondly, mianserin antagonized the inhibitory effect of clonidine on the electrically stimulated guinea-pig ileum. In high concentrations, mianserin reduced both electrically and acetylcholine induced contractions. Thirdly, mianserin antagonised the sleep induced by clonidine in chickens. These results are consistent with alpha 2-adrenoceptor blocking properties of mianserin in peripheral noradrenergic fibres in dogs, in cholinergic fibres in guinea-pig ileum and in the central nervous system in chickens.

Citing Articles

Measurement of 3-methoxy-4-hydroxyphenylglycol (MHPG) in mouse brain by h.p.l.c. with electrochemical detection, as an index of noradrenaline utilisation and presynaptic alpha 2-adrenoceptor function.

Heal D, Prow M, Buckett W Br J Pharmacol. 1989; 96(3):547-56.

PMID: 2541844 PMC: 1854396. DOI: 10.1111/j.1476-5381.1989.tb11852.x.

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