Genomic Arrangement of an Adenovirus-simian Virus 40 Hybrid Virus, Ad2+ND4del

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1981 Nov 1

PMID 6275101

Citations 10

Authors

H Westphal

Affiliations

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Abstract

Ad2+ND4del is an adenovirus type 2-simian virus 40 hybrid virus nondefective for growth in human cells. The virus was first observed when stocks of Ad2+ND4, a hybrid isolated from primary monkey kidney cells, were propagated in human cells. This paper describes the DNA sequence at two sites of DNA recombination, the site of the left adenovirus type 2-simian virus 40 junction and the site of a deletion of internal simian virus 40 sequences. Since the deletion was observed when the virus was switched from monkey to human cells, an analysis of gene expression in the region of DNA rearrangement may prove useful for the elucidation of molecular events that accompany virus growth in different hosts.

Citing Articles

DNA structure, and hemagglutination properties of bovine adenovirus type 2 strains which bypass species specificity.

Belak S, BERENCSI G, Rusvay M, Lukacs K, Nasz I Arch Virol. 1983; 77(2-4):181-94.

PMID: 6314935 DOI: 10.1007/BF01309266.

The adenovirus type 2-simian virus 40 hybrid virus Ad2+ND4 requires deletion variants to grow in monkey cells.

Lewis Jr A, Westphal H J Virol. 1983; 47(2):344-53.

PMID: 6312070 PMC: 255266. DOI: 10.1128/JVI.47.2.344-353.1983.

Quantitation of a simian virus 40 nonhomologous recombination pathway.

Dorsett D, Keshet I, Winocour E J Virol. 1983; 48(1):218-28.

PMID: 6310145 PMC: 255338. DOI: 10.1128/JVI.48.1.218-228.1983.

Sequence of the junction in adenovirus 2-SV40 hybrids: examples of illegitimate recombination.

Ling L, Manos M, Gluzman Y Nucleic Acids Res. 1982; 10(24):8099-112.

PMID: 6298708 PMC: 327072. DOI: 10.1093/nar/10.24.8099.

Palindromic adenovirus type 5-simian virus 40 hybrid.

Gluzman Y, Van Doren K J Virol. 1983; 45(1):91-103.

PMID: 6296462 PMC: 256390. DOI: 10.1128/JVI.45.1.91-103.1983.

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