Age Dependent Changes in the Methylation of Rat Brain Phospholipids

Overview

Journal Brain Res

Specialty Neurology

Date 1981 Dec 14

PMID 6272934

Citations 7

Authors

F T Crews

G Calderini

A Battistella

G Toffano

Affiliations

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Abstract

Phospholipid methyltransferase I and II enzymes methylate phosphatidylethanolamine three times to form phosphatidylcholine. The activity of these two enzymes was determined in synaptosome-enriched fractions from rats 1, 3, 7, 15 and 21 months old. The activity of phospholipid methyltransferase I was significantly greater in 7-, 15- and 21-month-old rats than in 1- and 3-month-old rats. In contrast, the activity of phospholipid methyltransferase II did not change with age. These changes in methyltransferase activity with increasing age may be related to changes in beta-receptor function with increasing age.

Citing Articles

Age-associated changes in central nervous system glycerolipid composition and metabolism.

Giusto N, Salvador G, Castagnet P, Pasquare S, Ilincheta de Boschero M Neurochem Res. 2003; 27(11):1513-23.

PMID: 12512956 DOI: 10.1023/a:1021604623208.

Sexually dimorphic activation of liver and brain phosphatidylethanolamine N-methyltransferase by dietary choline deficiency.

Johnson P, Blusztajn J Neurochem Res. 1998; 23(5):583-7.

PMID: 9566595 DOI: 10.1023/a:1022470301550.

Entry of polyunsaturated fatty acids into the brain: evidence that high-density lipoprotein-induced methylation of phosphatidylethanolamine and phospholipase A2 are involved.

Magret V, Elkhalil L, Martin F, Bourre J, Fruchart J, Delbart C Biochem J. 1996; 316 ( Pt 3):805-11.

PMID: 8670155 PMC: 1217421. DOI: 10.1042/bj3160805.

Biochemical changes of rat brain membranes with aging.

Calderini G, Bonetti A, Battistella A, Crews F, Toffano G Neurochem Res. 1983; 8(4):483-92.

PMID: 6310426 DOI: 10.1007/BF00965104.

Developmental changes in the activity of phosphatidylethanolamine N-methyltransferases in rat brain.

Blusztajn J, Zeisel S, Wurtman R Biochem J. 1985; 232(2):505-11.

PMID: 4091805 PMC: 1152909. DOI: 10.1042/bj2320505.