Suppression of Rabbit Peritoneal Macrophage Migration by Heat-labile E. Coli Toxin

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 1981 Mar 1

PMID 6262237

Authors

A H Cushing

S Murphy

B E Skipper

Affiliations

Soon will be listed here.

Abstract

Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.

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