Antidiuretic Effect of Beta-endorphin and Morphine in Brattleboro Rats: Development of Tolerance and Physical Dependence After Chronic Morphine Treatment

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1980 Jan 1

PMID 6258694

Citations 4

Authors

J P Huidobro-Toro

Affiliations

Soon will be listed here.

Abstract

1 beta-Endorphin (2 micrograms injected into the lateral ventricles) produced a significant decrease in the urine outflow and in the excretion of Na+ and K+ in Brattleboro rats, animals suffering from severe diabetes insipidus. Morphine intracerebrally also produced antidiuresis, as compared to saline-treated controls. 2 Morphine injected intraperitoneally caused a dose-dependent decrease in the urine outflow, and in the excretion of Na+ and K+. 3. Rats chronically treated with morphine (72 h of morphine pellet implantation) were less sensitive to the antidiuretic effect of a challenge dose of morphine than control Brattleboro rats implanted with placebo pellets, but otherwise treated similarly. 4 After chronic morphine administration, Brattleboro rats became dependent on morphine. Challenge with 1 mg/kg naloxone (s.c.) precipitated an abrupt opiate withdrawal syndrome characterized, among other symptoms, by increased urination in contrast to the antidiuresis observed before naloxone.

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References

Huidobro-Toro J, Huidobro F, CROXATTO R . Effects of beta-endorphin and D-alanine2 enkephalinamide on urine production and urinary electrolytes in the rat. Life Sci. 1979; 24(8):697-703. DOI: 10.1016/0024-3205(79)90351-5. View

TSENG L, Loh H, Li C . betah-endorphin: antidiuretic effects in rats. Int J Pept Protein Res. 1978; 12(3):173-6. DOI: 10.1111/j.1399-3011.1978.tb02882.x. View

Mills E, Wang S . LIBERATION OF ANTIDIURETIC HORMONE: PHARMACOLOGIC BLOCKADE OF ASCENDING PATHWAYS. Am J Physiol. 1964; 207:1405-10. DOI: 10.1152/ajplegacy.1964.207.6.1405. View

George R, WAY E . The role of the hypothalamus in pituitary-adrenal activation and antidiuresis by morphine. J Pharmacol Exp Ther. 1959; 125(2):111-5. View

Bolme P, Fuxe K, Agnati L, Bradley R, Smythies J . Cardiovascular effects of morphine and opioid peptides following intracisternal administration in chloralose-anesthetized rats. Eur J Pharmacol. 1978; 48(3):319-24. DOI: 10.1016/0014-2999(78)90090-0. View

Huidobro F . Antidiuretic effect of morphine in the rat: tolerance and physical dependence. Br J Pharmacol. 1978; 64(2):167-71. PMC: 1668303. DOI: 10.1111/j.1476-5381.1978.tb17286.x. View

de Wied D, Gispen W . Impaired development of tolerance to morphine analgesia in rats with hereditary diabetes insipidus. Psychopharmacologia. 1976; 46(1):27-9. DOI: 10.1007/BF00421545. View

Huidobro F . Antidiuretic effect of morphine and vasopressin in morphine tolerant and non-tolerant rats, differential effects on urine composition. Eur J Pharmacol. 1979; 59(1-2):55-64. DOI: 10.1016/0014-2999(79)90024-4. View

Handley C, KELLER A . Changes in renal function produced by morphine in normal dogs and dogs with diabetes insipidus. J Pharmacol Exp Ther. 1950; 99(1):33-7. View

10.

Schmidt W, Holaday J, Loh H, WAY E . Failure vasopressin and oxytocin to antagonize acute morphine antinociception or facilitate narcotic tolerance development. Life Sci. 1978; 23(2):151-8. DOI: 10.1016/0024-3205(78)90264-3. View

11.

Wei E, Loh H, WAY E . Quantitative aspects of precipitated abstinence in morphine-dependent rats. J Pharmacol Exp Ther. 1973; 184(2):398-403. View

12.

HARRINGTON A, VALTIN H . VASOPRESSIN EFFECT ON URINARY CONCENTRATION IN RATS WITH HEREDITARY HYPOTHALAMIC DIABETES INSIPIDUS (BRATTLEBORO STRAIN). Proc Soc Exp Biol Med. 1965; 118:448-50. DOI: 10.3181/00379727-118-29871. View

13.

Huidobro F, CROXATTO R, Huidobro-Toro J . Effect of morphine on the clearance of endogenous creatinine and blood clinical chemicals in the rat. Arch Int Pharmacodyn Ther. 1979; 237(1):31-41. View

14.

Krivoy W, Zimmermann E, Lande S . Facilitation of development of resistance to morphine analgesia by desglycinamide9-lysine vasopressin. Proc Natl Acad Sci U S A. 1974; 71(5):1852-6. PMC: 388340. DOI: 10.1073/pnas.71.5.1852. View

15.

Huidobro F, Huidobro J . Normorphine on noradrenaline hypertension. Arch Int Pharmacodyn Ther. 1970; 188(1):44-52. View

16.

LAUBIE M, Schmitt H, Vincent M, Remond G . Central cardiovascular effects of morphinomimetic peptides in dogs. Eur J Pharmacol. 1977; 46(1):67-71. DOI: 10.1016/0014-2999(77)90146-7. View

17.

Bisset G, Chowdrey H, FELDBERG W . Release of vasopressin by enkephalin. Br J Pharmacol. 1978; 62(3):370-1. PMC: 1668152. DOI: 10.1111/j.1476-5381.1978.tb08472.x. View

18.

VALTIN H, Schroeder H . FAMILIAL HYPOTHALAMIC DIABETES INSIPIDUS IN RATS (BRATTLEBORO STRAIN). Am J Physiol. 1964; 206:425-30. DOI: 10.1152/ajplegacy.1964.206.2.425. View

19.

FELDBERG W, Wei E . The central origin and mechanism of cardiovascular effects of morphine as revealed by naloxone in cats [proceedings]. J Physiol. 1977; 272(1):99P-100P. View

20.

WINTER C, GAFFNEY C, FLATAKER L . The effect of N-allylnormorphine upon the antidiuretic action of morphine. J Pharmacol Exp Ther. 1954; 111(3):360-4. View