Article: The effect on paracetamol absorption of stimulation and blockade of beta-adrenoceptors

1 The effect of drugs acting on beta-adrenoceptors on the absorption and excretion of paracetamol was studied in 26 volunteers and nine patients with mild hypertension, each subject acting as his/her own control. 2 Isoprenaline given 30 min before paracetamol significantly slowed absorption, the effect being dose related, and blocked by prior administration of propranolol. 3 When isoprenaline was given immediately before the paracetamol, absorption was not altered, although a cardiovascular response was seen. 4 Oral salbutamol also delayed paracetamol absorption. 5 Propranolol given alone increased the rate of paracetamol absorption. 6 These results with the changes in the rate of gastric emptying produced by these agents.

Citing Articles

Antecedent Hypoglycemia Does Not Attenuate the Acceleration of Gastric Emptying by Hypoglycemia.

Kar P, Jones K, Plummer M, Abdelhamid Y, Giersch E, Summers M J Clin Endocrinol Metab. 2017; 102(11):3953-3960.

PMID: 28973430 PMC: 5673277. DOI: 10.1210/jc.2017-00051.

Antro-pyloro-duodenal motor responses to gastric and duodenal nutrient in critically ill patients.

Chapman M, Fraser R, Vozzo R, Bryant L, Tam W, Nguyen N Gut. 2005; 54(10):1384-90.

PMID: 15923669 PMC: 1774690. DOI: 10.1136/gut.2005.065672.

Effects of preoperative anxiety on gastric fluid acidity and volume.

Hong J, Oh J J Korean Med Sci. 2005; 20(2):232-5.

PMID: 15831993 PMC: 2808598. DOI: 10.3346/jkms.2005.20.2.232.

Concomitant overdosing of other drugs in patients with paracetamol poisoning.

Schmidt L, Dalhoff K Br J Clin Pharmacol. 2002; 53(5):535-41.

PMID: 11994060 PMC: 1874350. DOI: 10.1046/j.1365-2125.2002.01564.x.

Pharmacokinetic drug interactions with gastrointestinal motility modifying agents.

Greiff J, Rowbotham D Clin Pharmacokinet. 1994; 27(6):447-61.

PMID: 7882635 DOI: 10.2165/00003088-199427060-00004.

References

1.

LEVINE R . Factors affecting gastrointestinal absorption of drugs. Am J Dig Dis. 1970; 15(2):171-88. DOI: 10.1007/BF02235648. View

2.

Consolo S, Morselli P, ZACCALA M, Garattini S . Delayed absorption of phenylbutazone caused by desmethylimipramine in humans. Eur J Pharmacol. 1970; 10(2):239-42. DOI: 10.1016/0014-2999(70)90278-5. View

3.

Prescott L . The gas-liquid chromatographic estimation of phenacetin and paracetamol in plasma and urine. J Pharm Pharmacol. 1971; 23(2):111-5. DOI: 10.1111/j.2042-7158.1971.tb08622.x. View

4.

BIANCHINE J, Calimlim L, Morgan J, Dujuvne C, Lasagna L . Metabolism and absorption of L-3,4 dihydroxyphenylalanine in patients with Parkinson's disease. Ann N Y Acad Sci. 1971; 179:126-40. DOI: 10.1111/j.1749-6632.1971.tb46895.x. View

5.

Prescott L . Gas-liquid chromatographic estimation of paracetamol. J Pharm Pharmacol. 1971; 23(10):807-8. DOI: 10.1111/j.2042-7158.1971.tb08613.x. View

6.

Levy G, Gibaldi M, PROCKNAL J . Effect of an anticholinergic agent on riboflavin absorption in man. J Pharm Sci. 1972; 61(5):798-9. DOI: 10.1002/jps.2600610529. View

7.

Manninen V, Apajalahti A, Melin J, Karesoja M . Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet. 1973; 1(7800):398-400. DOI: 10.1016/s0140-6736(73)90252-3. View

8.

Nimmo J, Heading R, Tothill P, Prescott L . Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. Br Med J. 1973; 1(5853):587-9. PMC: 1589913. DOI: 10.1136/bmj.1.5853.587. View

9.

Talbot R, Nimmo J, Julian D, Clark R, Neilson J, Prescott L . Treatment of ventricular arrhythmias with mexiletine (Kö 1173). Lancet. 1973; 2(7826):399-404. DOI: 10.1016/s0140-6736(73)92270-8. View

10.

Castaneda L, Lasagna L . Effects of mode of management on plasma chlorpromazine in psychiatric patients. Clin Pharmacol Ther. 1973; 14(6):978-86. DOI: 10.1002/cpt1973146978. View

11.

Hall R, Brown D, Carter R, Kendall M . The effect of desmethylimipramine on the absorption of alcohol and paracetamol. Postgrad Med J. 1976; 52(605):139-42. PMC: 2496385. DOI: 10.1136/pgmj.52.605.139. View

12.

Marcus C, Lengemann F . Absorption of Ca45 and Sr85 from solid and liquid food at various levels of the alimentary tract of the rat. J Nutr. 1962; 77:155-60. DOI: 10.1093/jn/77.2.155. View

The Effect on Paracetamol Absorption of Stimulation and Blockade of Beta-adrenoceptors