Evidence for a Direct Inhibitory Effect of Morphine on the Secretion of Posterior Pituitary Hormones

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1980 Sep 5

PMID 6252017

Citations 8

Authors

B Lutz-Bucher

B Koch

Affiliations

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Abstract

The effect of morphine and naloxone on vasopressin and oxytocin release from incubated neurointermediate lobe and pars nervosa of rat pituitaries were investigated. It was shown that morphine and endorphins blocked hormonal output and that this inhibitory action was reversed by naloxone. It is concluded that opiates exert a direct inhibitory influence on vasopressin and oxytocin secretions from the neurohypophysis.

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