Do Opioid Peptides Modulate, at the Level of the Nerve Endings, the Release of Neurohypophysial Hormones?

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1986 Jan 1

PMID 3514253

Citations 9

Authors

J J Nordmann

G Dayanithi

M Cazalis

Affiliations

Soon will be listed here.

Abstract

Rat neurointermediate lobes and neurohypophyses separated from the pars intermedia were stimulated in vitro in the presence of either D-Ala2, D-Leu5-enkephalin (DADLE), a Leu-enkephalin stable analogue or FK 33-824 a Met-enkephalin stable analogue. Secretion of vasopressin (AVP) and oxytocin (OT) was produced by either a Ca2+-ionophore or with electrical stimulation or by K+-induced depolarization. These opioid peptides and their antagonist naloxone did not affect basal nor evoked hormone release. Furthermore, they did not affect the evoked calcium uptake induced with electrical stimulation. These findings were confirmed using a preparation of isolated neurosecretory nerve endings. Further, dopamine had no effect on the K+-induced AVP release although a crude extract of the pars intermedia abolished the electrically-evoked and reduced considerably the potassium-evoked AVP release. It is concluded that in the neurohypophysis neither Leu- and Met-enkephalin nor dopamine affect the secretion-coupling mechanism at the level of the neurosecretory nerve endings.

Citing Articles

Tomosyn Negatively Regulates Arginine Vasopressin Secretion in Embryonic Stem Cell-Derived Neurons.

Takeuchi S, Iwama S, Takagi H, Kiyota A, Nakashima K, Izumida H PLoS One. 2016; 11(10):e0164544.

PMID: 27732637 PMC: 5061411. DOI: 10.1371/journal.pone.0164544.

Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals.

Ortiz-Miranda S, Dayanithi G, Velazquez-Marrero C, Custer E, Treistman S, Lemos J J Cell Physiol. 2010; 225(1):276-88.

PMID: 20509142 PMC: 4060829. DOI: 10.1002/jcp.22263.

Electrical properties of axons and neurohypophysial nerve terminals and their relationship to secretion in the rat.

Nordmann J, Stuenkel E J Physiol. 1986; 380:521-39.

PMID: 3612574 PMC: 1182952. DOI: 10.1113/jphysiol.1986.sp016300.

Depolarization-induced Ca2+ increase in isolated neurosecretory nerve terminals measured with fura-2.

Brethes D, Dayanithi G, Letellier L, Nordmann J Proc Natl Acad Sci U S A. 1987; 84(5):1439-43.

PMID: 3469676 PMC: 304446. DOI: 10.1073/pnas.84.5.1439.

Opiate binding differentially associated with oxytocin and vasopressin nerve endings from porcine neurohypophyses.

Falke N, Martin R Exp Brain Res. 1988; 70(1):145-54.

PMID: 3402560 DOI: 10.1007/BF00271856.

References

Usategui R, Oliver C, Vaudry H, Lombardi G, Rozenberg I, Mourre A . Immunoreactive alpha-MSH and ACTH levels in rat plasma and pituitary. Endocrinology. 1976; 98(1):189-96. DOI: 10.1210/endo-98-1-189. View

Bicknell R, Leng G . Relative efficiency of neural firing patterns for vasopressin release in vitro. Neuroendocrinology. 1981; 33(5):295-9. DOI: 10.1159/000123248. View

Firemark H, Weitzman R . Effects of beta-endorphin, morphine and naloxone on arginine vasopressin secretion and the electroencephalogram. Neuroscience. 1979; 4(12):1895-902. DOI: 10.1016/0306-4522(79)90063-0. View

Lutz-Bucher B, Koch B . Evidence for a direct inhibitory effect of morphine on the secretion of posterior pituitary hormones. Eur J Pharmacol. 1980; 66(4):375-8. DOI: 10.1016/0014-2999(80)90470-7. View

Lightman S, Ninkovic M, Hunt S, Iversen L . Evidence for opiate receptors on pituicytes. Nature. 1983; 305(5931):235-7. DOI: 10.1038/305235a0. View

Kumar M, Chen C, Muther T . Changes in the pituitary and hypothalamic content of methionine-enkephalin during the estrous cycle of rats. Life Sci. 1979; 25(19):1687-96. DOI: 10.1016/0024-3205(79)90410-7. View

Dutton A, Dyball R . Phasic firing enhances vasopressin release from the rat neurohypophysis. J Physiol. 1979; 290(2):433-40. PMC: 1278845. DOI: 10.1113/jphysiol.1979.sp012781. View

Goldstein A, Ghazarossian V . Immunoreactive dynorphin in pituitary and brain. Proc Natl Acad Sci U S A. 1980; 77(10):6207-10. PMC: 350244. DOI: 10.1073/pnas.77.10.6207. View

Pitzel L, Konig A . Lack of response in the release of oxytocin and vasopressin from isolated neurohypophyses to dopamine, met-enkephalin and leu-enkephalin. Exp Brain Res. 1984; 56(2):221-6. DOI: 10.1007/BF00236277. View

10.

Cazalis M, Dayanithi G, Nordmann J . The role of patterned burst and interburst interval on the excitation-coupling mechanism in the isolated rat neural lobe. J Physiol. 1985; 369:45-60. PMC: 1192635. DOI: 10.1113/jphysiol.1985.sp015887. View

11.

Rossier J, Vargo T, Minick S, Ling N, Bloom F, Guillemin R . Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proc Natl Acad Sci U S A. 1977; 74(11):5162-5. PMC: 432121. DOI: 10.1073/pnas.74.11.5162. View

12.

Ito S, Iwanaga T, Yui R, Yamaguchi K, Hama H, Kamoi K . Presence of alpha-neo-endorphin-like immunoreactivity in the posterior lobe of the pituitary gland. Life Sci. 1981; 29(14):1457-61. DOI: 10.1016/0024-3205(81)90010-2. View

13.

DOUGLAS W, Poisner A . STIMULUS-SECRETION COUPLING IN A NEUROSECRETORY ORGAN: THE ROLE OF CALCIUM IN THE RELEASE OF VASOPRESSIN FROM THE NEUROHYPOPHYSIS. J Physiol. 1964; 172:1-18. PMC: 1368899. DOI: 10.1113/jphysiol.1964.sp007399. View

14.

Bridges T, Hillhouse E, Jones M . The effect of dopamine on neurohypophysial hormone release in vivo and from the rat neural lobe and hypothalamus in vitro. J Physiol. 1976; 260(3):647-66. PMC: 1309116. DOI: 10.1113/jphysiol.1976.sp011537. View

15.

Nordmann J . Stimulus-secretion coupling. Prog Brain Res. 1983; 60:281-304. DOI: 10.1016/S0079-6123(08)64397-6. View

16.

Weber E, Evans C, Barchas J . Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions. Nature. 1982; 299(5878):77-9. DOI: 10.1038/299077a0. View

17.

Nakao K, Yoshimasa T, Oki S, Tanaka I, Nakai Y, Wakimasu M . Presence of dynorphin-like immunoreactivity in rat pituitary gland and hypothalamus. Regul Pept. 1981; 2(3):201-8. DOI: 10.1016/0167-0115(81)90014-8. View

18.

Lightman S, Iversen L, Forsling M . Dopamine and [D-ALA2, D-Leu5]enkephalin inhibit the electrically stimulated neurohypophyseal release of vasopressin in vitro: evidence for calcium-dependent opiate action. J Neurosci. 1982; 2(1):78-81. PMC: 6564287. View

19.

Dreifuss J, Grau J, Bianchi R . Antagonism between Ca and Na ions at neurohypophysial nerve terminals. Experientia. 1971; 27(11):1295-6. DOI: 10.1007/BF02136696. View

20.

Clarke G, Wood P, Merrick L, Lincoln D . Opiate inhibition of peptide release from the neurohumoral terminals of hypothalamic neurones. Nature. 1979; 282(5740):746-8. DOI: 10.1038/282746a0. View