Genetic Mapping of Xenotropic Murine Leukemia Virus-inducing Loci in Five Mouse Strains

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1980 Jul 1

PMID 6249881

Citations 47

Authors

C A Kozak

W P Rowe

Affiliations

Soon will be listed here.

Abstract

A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.

Citing Articles

Distribution of endogenous gammaretroviruses and variants of the Fv1 restriction gene in individual mouse strains and strain subgroups.

Skorski M, Bamunusinghe D, Liu Q, Shaffer E, Kozak C PLoS One. 2019; 14(7):e0219576.

PMID: 31291374 PMC: 6619830. DOI: 10.1371/journal.pone.0219576.

Xenotropic Mouse Gammaretroviruses Isolated from Pre-Leukemic Tissues Include a Recombinant.

Bamunusinghe D, Skorski M, Buckler-White A, Kozak C Viruses. 2018; 10(8).

PMID: 30096897 PMC: 6116186. DOI: 10.3390/v10080418.

Recombinant Origins of Pathogenic and Nonpathogenic Mouse Gammaretroviruses with Polytropic Host Range.

Bamunusinghe D, Liu Q, Plishka R, Dolan M, Skorski M, Oler A J Virol. 2017; 91(21).

PMID: 28794032 PMC: 5640873. DOI: 10.1128/JVI.00855-17.

Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo.

Naseer A, Terry A, Gilroy K, Kilbey A, Watts C, Mackay N Viruses. 2015; 7(4):2014-29.

PMID: 25912714 PMC: 4411688. DOI: 10.3390/v7042014.

Resurrection of endogenous retroviruses in antibody-deficient mice.

Young G, Eksmond U, Salcedo R, Alexopoulou L, Stoye J, Kassiotis G Nature. 2012; 491(7426):774-8.

PMID: 23103862 PMC: 3511586. DOI: 10.1038/nature11599.

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