Specificity of Initiation Factor Preparations from Poliovirus-infected Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1980 May 1

PMID 6246283

Citations 4

Authors

D Brown

J Hansen

E EHRENFELD

Affiliations

Soon will be listed here.

Abstract

Crude initiation factor preparations from poliovirus-infected cells stimulated the translation of poliovirus RNA in vitro, but were inactive for the translation of host cell or vesicular stomatitis virus mRNA's. In contrast, similar preparations from either uninfected or vesicular stomatitis virus-infected cells supported the initiation of translation of host cell mRNA's and both viral mRNA's. These results reflect a specific alteration of some components(s) of the initiation factor preparation from poliovirus-infected cells which is consistent with the ability of the virus to inhibit the translation of host cell and vesicular stomatitis virus-directed protein synthesis.

Citing Articles

Cross-linking of mRNA to initiation factor eIF-3, 24 kDa cap binding protein and ribosomal proteins S1, S3/3a, S6 and S11 within the 48S pre-initiation complex.

Westermann P, Nygard O Nucleic Acids Res. 1984; 12(23):8887-97.

PMID: 6514574 PMC: 320426. DOI: 10.1093/nar/12.23.8887.

Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells.

Hansen J, Etchison D, Hershey J, EHRENFELD E J Virol. 1982; 42(1):200-7.

PMID: 6283140 PMC: 256061. DOI: 10.1128/JVI.42.1.200-207.1982.

Presence of the cap-binding protein in initiation factor preparations from poliovirus-infected HeLa cells.

Hansen J, EHRENFELD E J Virol. 1981; 38(2):438-45.

PMID: 6264121 PMC: 171175. DOI: 10.1128/JVI.38.2.438-445.1981.

Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: relationship to p220 cleavage.

Lloyd R, Jense H, EHRENFELD E J Virol. 1987; 61(8):2480-8.

PMID: 3037110 PMC: 255675. DOI: 10.1128/JVI.61.8.2480-2488.1987.

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