A Relationship Between Plasmid Structure, Structural Lability, and Sensitivity to Site-specific Endonucleases in Neisseria Gonorrhoeae

Overview

Journal Mol Gen Genet

Specialties Genetics
Molecular Biology

Date 1980 Jan 1

PMID 6245338

Citations 8

Authors

J K Davies

S Normark

Affiliations

Soon will be listed here.

Abstract

Nearly all gonococcal strains carry a small "phenotypically cryptic" plasmid of approximately 4,200 basepairs. A detailed physical map of this plasmid has been constructed, revealing the presence of numerous putative inverted repeats. These studies also revealed the presence on the plasmid of recognition sequences for several site-specific endonucleases (particularly HpaII, MspI and AluI) that are particularly resistant to cleavage, and confirmed previous reports of structural lability. Both the sites that are resistant to cleavage, and the observed structural variation are associated with the inverted repetitive sequences.

Citing Articles

Relationship between plasmid content and auxotype in Neisseria gonorrhoeae isolates.

Dillon J, Pauze M Infect Immun. 1981; 33(2):625-8.

PMID: 6792083 PMC: 350746. DOI: 10.1128/iai.33.2.625-628.1981.

Plasmids in throat and genital isolates of meningococci.

Ison C, Bellinger C, GLYNN A J Clin Pathol. 1984; 37(10):1123-8.

PMID: 6436336 PMC: 498952. DOI: 10.1136/jcp.37.10.1123.

Characterization of concatemeric plasmids of Neisseria gonorrhoeae.

Johnson S, Anderson B, Biddle J, Perkins G, DeWitt W Infect Immun. 1983; 40(2):843-6.

PMID: 6404838 PMC: 264934. DOI: 10.1128/iai.40.2.843-846.1983.

Sequence-specific DNA uptake in transformation of Neisseria gonorrhoeae.

GRAVES J, Biswas G, Sparling P J Bacteriol. 1982; 152(3):1071-7.

PMID: 6292160 PMC: 221611. DOI: 10.1128/jb.152.3.1071-1077.1982.

Homology of cryptic plasmid of Neisseria gonorrhoeae with plasmids from Neisseria meningitidis and Neisseria lactamica.

Ison C, Bellinger C, Walker J J Clin Pathol. 1986; 39(10):1119-23.

PMID: 3097079 PMC: 500234. DOI: 10.1136/jcp.39.10.1119.

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