Duodeno-pancreatic Secretions Enhance Bactericidal Activity of Antimicrobial Drugs

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1984 Jul 1

PMID 6236746

Citations 9

Authors

H Mett

K Gyr

O Zak

K Vosbeck

Affiliations

Soon will be listed here.

Abstract

We have studied the action of various antimicrobial agents in microbiological media and in human duodeno-pancreatic secretions. In the latter medium, clioquinol exhibited a rapid bactericidal effect on both growing and stationary bacteria at concentrations near its MIC. However, it was merely bacteriostatic in microbiological media, even at high concentrations. Phanquinone, chlorquinaldol, and, to a lesser extent, also chloramphenicol and trimethoprim likewise displayed enhanced bactericidal activity in duodeno-pancreatic secretions, but various other antibacterial agents did not. These findings suggest that duodeno-pancreatic secretions contain a factor augmenting the antibacterial activity of a number of drugs.

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