Rosoxacin in the Treatment of Uncomplicated Gonorrhoea in Men

Overview

Journal Br J Vener Dis

Specialty Infectious Diseases

Date 1984 Aug 1

PMID 6234966

Citations 2

Authors

K Panikabutra

C Ariyarit

A Chitwarakorn

C Saensanoh

Affiliations

Soon will be listed here.

Abstract

Between 3 January and 4 March 1983 we treated 200 male patients diagnosed as having uncomplicated gonococcal urethritis with one of two regimens. They were divided into two groups and randomly assigned to treatment with either 2 g spectinomycin administered intramuscularly (group A) or 300 mg rosoxacin by mouth (group B). Of 187 isolates tested for the production of beta-lactamase, 101 (54%) were penicillinase producing Neisseria gonorrhoeae (PPNG) strains. All 81 cases followed in group A (spectinomycin) were cured, compared with 88.5% (77 out of 87) of the patients followed in group B (rosoxacin). We concluded that rosoxacin at a dosage of 300 mg administered orally was fairly effective in the treatment of gonococcal urethritis in men caused by both PPNG and non-PPNG strains.

Citing Articles

Single dose intramuscular sulbactam and ampicillin in treating acute uncomplicated gonorrhoea.

Houang E, Reardon P Genitourin Med. 1985; 61(3):209.

PMID: 2989156 PMC: 1011806. DOI: 10.1136/sti.61.3.209.

Treating gonococcal infections resistant to penicillin in Bangkok: comparison of cefuroxime and spectinomycin.

Chitwarakorn A, Ariyarit C, Panikabutra K, Buateing A, Biddle J, Thompson S Genitourin Med. 1985; 61(5):306-10.

PMID: 2931346 PMC: 1011844. DOI: 10.1136/sti.61.5.306.

References

Handsfield H, Holmes K . Treatment of uncomplicated gonorrhea with cefotaxime. Sex Transm Dis. 1981; 8(3):187-91. DOI: 10.1097/00007435-198107000-00003. View

. Spectinomycin-resistant penicillinase-producing Neisseria gonorrhoeae--California. MMWR Morb Mortal Wkly Rep. 1981; 30(19):221-2. View

Easmon C, Ison C, Bellinger C, Harris J . Emergence of resistance after spectinomycin treatment for gonorrhoea due to beta-lactamase producing strain of Neisseria gonorrhoeae. Br Med J (Clin Res Ed). 1982; 284(6329):1604-5. PMC: 1498550. DOI: 10.1136/bmj.284.6329.1604. View

Woscoff A, Flichman J, Man F, Martinez T, de Martinez L, Chouela E . Rosoxacin (Win 35,213) in the treatment of uncomplicated acute gonococcal infection. Clin Ther. 1982; 4(6):515-25. View

Calubiran O, Tupasi T, Torres C, LIMSON B . Treatment of uncomplicated gonorrhoea in women. Comparison of rosoxacin and spectinomycin. Br J Vener Dis. 1982; 58(4):231-5. PMC: 1046055. DOI: 10.1136/sti.58.4.231. View

Panikabutra K, Ariyarit C, Chitwarakorn A, Warnisorn T . Cefotaxime in the treatment of gonorrhoea caused by penicillinase producing N. gonorrhoeae (PPNG) and non penicillinase producing N. gonorrhoeae (Non PPNG). J Med Assoc Thai. 1982; 65(5):271-6. View

Rajan V, Sng E, Thirumoorthy T, Goh C . Ceftriaxone in the treatment of ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1982; 58(5):314-6. PMC: 1046083. DOI: 10.1136/sti.58.5.314. View

Panikabutra K, Ariyarit C, Chitwarakorn A, Warnnissorn T, Saensanoh C . Sensitivity to penicillin, thiamphenicol, kanamycin, cefoxitin and spectinomycin of penicillinase-producing Neisseria gonorrhoeae (PPNG) in Bangkok. Relation to the results of treatment. J Med Assoc Thai. 1982; 65(6):316-24. View

Siegel M, THOMPSON S, Perine P, Brown S, Reynolds G, Thornsberry C . Treatment of uncomplicated gonococcal urethritis with cefoxitin: comparison with penicillin. Rev Infect Dis. 1979; 1(1):183-8. DOI: 10.1093/clinids/1.1.183. View

10.

Jaffe H, Biddle J, Thornsberry C, Johnson R, KAUFMAN R, Reynolds G . National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976; 294(1):5-9. DOI: 10.1056/NEJM197601012940102. View

11.

McCormack W . Treatment of gonorrhea -- is penicillin passé?. N Engl J Med. 1977; 296(16):934-6. DOI: 10.1056/NEJM197704212961610. View

12.

Siegel M, THOMPSON S, Perine P . Penicillinase-producing neisseria gonorrhoeae. Sex Transm Dis. 1977; 4(1):32-3. View

13.

Berg S, Kilpatrick M, HARRISON W, McCutchan J . Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979; 301(10):509-11. DOI: 10.1056/NEJM197909063011001. View

14.

Jones R, Stimson J, COUNTS G, Holmes K . Cefoxitin in the treatment of gonorrhea. Sex Transm Dis. 1979; 6(4):239-42. DOI: 10.1097/00007435-197910000-00002. View

15.

Rajan V, Sng E, Pang R, Tan N, Thirumoorthy T, Yeo K . HR 756--a new cephalosporin in the treatment of gonorrhoea caused by ordinary and penicillinase-producing strains of Neisseria gonorrhoeae. Br J Vener Dis. 1980; 56(4):255-8. PMC: 1045791. DOI: 10.1136/sti.56.4.255. View

16.

Seth A . Sensitivity of gonococci to rosoxacin compared with that of penicillin, cefuroxime and tetracycline. J Antimicrob Chemother. 1981; 7(4):331-4. DOI: 10.1093/jac/7.4.331. View

17.

LIMSON B, Macasaet R . Single oral dose rosoxacin in the treatment of gonorrhoea in males. J Int Med Res. 1982; 10(1):42-5. DOI: 10.1177/030006058201000109. View