Selective IgA Deficiency: Analysis of Ig Production in Vitro

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 1984 May 1

PMID 6234324

Citations 4

Authors

T Inoue

H Okubo

J Kudo

T Ikuta

K Hachimine

R Shibata

O Yoshinari

K Fukada

T Yanase

Affiliations

Soon will be listed here.

Abstract

The cellular basis of the pathogenesis of selective IgA deficiency (SIgAD) was investigated by examining surface immunoglobulin (SmIg) and in vitro pokeweed mitogen (PWM)-stimulated immunoglobulin (Ig) synthesis and by assaying in combination the counterpart lymphocytes from individuals with SIgAD and healthy donors. Peripheral blood lymphocytes (PBL) from 14 individuals with SIgAD synthesized normal amounts of IgG and IgM but did not synthesize normal amounts of IgA. Functional defects of lymphocytes for IgA synthesis were classified into four types: (i) B-lymphocyte dysfunction, (ii) increased function of suppressor T lymphocytes (Ts), (iii) decreased function of helper T lymphocytes (Th), and (iv) B-lymphocyte dysfunction and increased Ts function. The cells bearing SmIgG, SmIgM, and SmIgD were demonstrated at normal percentage ratios in all cases by immunofluorescent staining. The cells bearing SmIgA were at normal percentage ratios in the cases of T-lymphocyte dysfunction, while in the cases of B-lymphocyte defect SmIgA-bearing cells were reduced.

Citing Articles

Interleukin-10 polymorphisms in Spanish IgA deficiency patients: a case-control and family study.

Ortiz J, Fernandez-Arquero M, Urcelay E, Lopez-Mejias R, Ferreira A, Fontan G BMC Med Genet. 2006; 7:56.

PMID: 16803619 PMC: 1526417. DOI: 10.1186/1471-2350-7-56.

Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA.

Briere F, Bridon J, Chevet D, Souillet G, Bienvenu F, Guret C J Clin Invest. 1994; 94(1):97-104.

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Analysis of IgG subclass production in cell cultures from IgA deficient patients and in normal controls as a function of age.

Luzi G, Kubagawa H, Crain M, Cooper M Clin Exp Immunol. 1986; 65(2):434-42.

PMID: 3791704 PMC: 1542324.

Selective partial IgM deficiency: functional assessment of T and B lymphocytes in vitro.

Inoue T, Okumura Y, Shirama M, Ishibashi H, Kashiwagi S, Okubo H J Clin Immunol. 1986; 6(2):130-5.

PMID: 2872228 DOI: 10.1007/BF00918745.

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