Selective IgA Deficiency: Clinical and Immunological Evaluation of 50 Pediatric Patients

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1980 Mar 1

PMID 6444875

Citations 26

Authors

G R Burgio

M Duse

V Monafo

A Ascione

L Nespoli

Affiliations

Soon will be listed here.

Abstract

Fifty children with IgA deficiency were folllowed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (less than 2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of IgA had recurrent respiratory and/or gastrointestinal infections, about half with onset in the first year of life, while partial deficiency of IgA has probably little if any importance for anti-infectious immunity but is important in the pathogenesis of atopy. Atopic diseases were frequent in both groups. Chromosomal abnormalities were found in 2 patients: trisomy 21 in one and in the other a ring chromosome 18. No important defects in cellular immunity were detected but some isolated, borderline abnormalities were often present.

Citing Articles

The Allergic Phenotype of Children and Adolescents with Selective IgA Deficiency: A Longitudinal Monocentric Study.

Cinicola B, Brindisi G, Capponi M, Gori A, Loffredo L, Castro G J Clin Med. 2022; 11(19).

PMID: 36233573 PMC: 9573591. DOI: 10.3390/jcm11195705.

Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story.

Cinicola B, Pulvirenti F, Capponi M, Bonetti M, Brindisi G, Gori A Medicina (Kaunas). 2022; 58(1).

PMID: 35056437 PMC: 8781177. DOI: 10.3390/medicina58010129.

The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency.

Morawska I, Kurkowska S, Bebnowska D, Hrynkiewicz R, Becht R, Michalski A J Clin Med. 2021; 10(17).

PMID: 34501259 PMC: 8432128. DOI: 10.3390/jcm10173809.

Innate Mechanisms in Selective IgA Deficiency.

Zhang J, van Oostrom D, Li J, Savelkoul H Front Immunol. 2021; 12:649112.

PMID: 33981304 PMC: 8107477. DOI: 10.3389/fimmu.2021.649112.

Role of IgA in the early-life establishment of the gut microbiota and immunity: Implications for constructing a healthy start.

Guo J, Ren C, Han X, Huang W, You Y, Zhan J Gut Microbes. 2021; 13(1):1-21.

PMID: 33870860 PMC: 8078773. DOI: 10.1080/19490976.2021.1908101.

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