Role of Normal Adherent Cells in the Regulation of the Autologous Mixed Lymphocyte Reactions in Humans

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 1984 May 1

PMID 6234323

Authors

I Pierri

S Rogna

D Pende

D Viglione

M Scudeletti

A Barabino

F Indiveri

Affiliations

Soon will be listed here.

Abstract

The effect of normal adherent suppressor cells on the blastogenesis of human T lymphocytes in the mixed lymphocyte reaction (MLR) was studied in both allogeneic and autologous combinations. Non-T cells and Ia+ T lymphocytes were used as stimulator cells in both allogeneic and autologous MLR. The addition of adherent cells to the stimulators inhibited blastogenesis of T lymphocytes in both types of MLR when the stimulator population was made up of non-T lymphocytes but did not interfere with blastogenesis when Ia+ T lymphocytes were used as stimulator cells. The present data indicate that the T lymphocytes able to respond to Ia+ T cells (in the MLR, autologous or allogeneic) may be different from those which respond to non-T lymphocytes or may be less sensitive to the regulatory function of normal adherent cells.

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