Arthritis Induced in Rats by Cloned T Lymphocytes Responsive to Mycobacteria but Not to Collagen Type II

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1984 Jan 1

PMID 6228565

Citations 75

Authors

J Holoshitz

A Matitiau

I R Cohen

Affiliations

Soon will be listed here.

Abstract

We have been studying the pathogenesis of adjuvant arthritis in rats using a long-term cell line of T lymphocytes, the A2 line, which can induce polyarthritis and can also be used to vaccinate rats against adjuvant arthritis. Although line A2 was selected for its proliferative response to mycobacteria, it also responded to collagen type II. To elucidate its role of responsiveness to collagen type II and the relationship between arthritogenicity and vaccination, we cloned A2 and selected a subline A2b. We now report that subline A2b, which bore a marker of helper/delayed hypersensitivity T lymphocytes, was strongly arthritogenic, but could not vaccinate against arthritis. Moreover, A2b showed no response to collagen type II. Therefore, reactivity to collagen type II is not a requisite for arthritogenicity, and mediation of arthritis and vaccination can be distinct properties of different populations of T lymphocytes.

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References

Ben-Nun A, Wekerle H, Cohen I . Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein. Nature. 1981; 292(5818):60-1. DOI: 10.1038/292060a0. View

Trentham D, Townes A, Kang A . Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977; 146(3):857-68. PMC: 2180804. DOI: 10.1084/jem.146.3.857. View

Taurog J, Sandberg G, Mahowald M . The cellular basis of adjuvant arthritis. I. Enhancement of cell-mediated passive transfer by concanavalin A and by immunosuppressive pretreatment of the recipient. Cell Immunol. 1983; 75(2):271-82. DOI: 10.1016/0008-8749(83)90325-8. View

Quagliata F . Competence of thoracic duct cells in the transfer of adjuvant disease and delayed hypersensitivity. Evidence that mycobacterial components are required for the successful transfer of the disease. Cell Immunol. 1972; 3(1):78-87. DOI: 10.1016/0008-8749(72)90228-6. View

Stuart J, Cremer M, Townes A, Kang A . Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis. J Exp Med. 1982; 155(1):1-16. PMC: 2186578. DOI: 10.1084/jem.155.1.1. View

Pearson C, WOOD F . PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLS. J Exp Med. 1964; 120:547-60. PMC: 2137780. DOI: 10.1084/jem.120.4.547. View

Trentham D, Dynesius R, Rocklin R, David J . Cellular sensitivity to collagen in rheumatoid arthritis. N Engl J Med. 1978; 299(7):327-32. DOI: 10.1056/NEJM197808172990703. View

Pearson C . Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956; 91(1):95-101. DOI: 10.3181/00379727-91-22179. View

Iizuka Y, Chang Y . Adjuvant polyarthritis. VII. The role of type II collagen in pathogenesis. Arthritis Rheum. 1982; 25(11):1325-32. DOI: 10.1002/art.1780251108. View

10.

Trentham D, McCune W, Susman P, David J . Autoimmunity to collagen in adjuvant arthritis of rats. J Clin Invest. 1980; 66(5):1109-17. PMC: 371549. DOI: 10.1172/JCI109940. View

11.

Berry H, Willoughby D, Giroud J . Evidence for an endogenous antigen in the adjuvant arthritic rat. J Pathol. 1973; 111(4):229-38. DOI: 10.1002/path.1711110403. View

12.

Pearson C . EXPERIMENTAL MODELS IN RHEUMATOID DISEASE. Arthritis Rheum. 1964; 7:80-6. DOI: 10.1002/art.1780070111. View

13.

Naparstek Y, Ben-Nun A, Holoshitz J, Reshef T, Frenkel A, Rosenberg M . T lymphocyte lines producing or vaccinating against autoimmune encephalomyelitis (EAE). Functional activation induces peanut agglutinin receptors and accumulation in the brain and thymus of line cells. Eur J Immunol. 1983; 13(5):418-23. DOI: 10.1002/eji.1830130513. View

14.

Ben-Nun A, Cohen I . Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. J Immunol. 1982; 129(1):303-8. View

15.

Duksin D, Maoz A, Fuchs S . Differential cytotoxic acitivity of anticollagen serum on rat osteoblasts and fibroblasts in tissue culture. Cell. 1975; 5(1):83-6. DOI: 10.1016/0092-8674(75)90095-1. View

16.

Holoshitz J, Naparstek Y, Ben-Nun A, Cohen I . Lines of T lymphocytes induce or vaccinate against autoimmune arthritis. Science. 1983; 219(4580):56-8. DOI: 10.1126/science.6336851. View