Bactericidal and Synergistic Activity of Moxalactam Alone and in Combination with Gentamicin Against Pseudomonas Aeruginosa

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1983 Jan 1

PMID 6219619

Citations 8

Authors

P K Yu

R S Edson

J A Washington 2nd

P E HERMANS

Affiliations

Soon will be listed here.

Abstract

The bactericidal activity of moxalactam, alone and in combination with gentamicin, was studied with macrobroth two-dimensional checkerboard and killing curve techniques against gentamicin-resistant and -susceptible strains of Pseudomonas aeruginosa. Moxalactam was bactericidal at concentrations equal to or at least two to four times its inhibitory concentrations. Synergy at clinically applicable concentrations of moxalactam and gentamicin occurred with 6 of 14 gentamicin-resistant strains and 4 of 4 gentamicin-susceptible strains by the checkerboard technique and with 7 of 14 gentamicin-resistant strains by the killing curve technique. Synergy between moxalactam and gentamicin against gentamicin-resistant strains of P. aeruginosa is unpredictable and strain- and method-dependent.

Citing Articles

In vitro activity of aztreonam in combination with newer beta-lactams and amikacin against multiply resistant gram-negative bacilli.

Buesing M, Jorgensen J Antimicrob Agents Chemother. 1984; 25(2):283-5.

PMID: 6538773 PMC: 185492. DOI: 10.1128/AAC.25.2.283.

Synergistic activities of combinations of beta-lactams, fosfomycin, and tobramycin against Pseudomonas aeruginosa.

Takahashi K, Kanno H Antimicrob Agents Chemother. 1984; 26(5):789-91.

PMID: 6440482 PMC: 180018. DOI: 10.1128/AAC.26.5.789.

In vitro synergistic activities of aminoglycosides and new beta-lactams against multiresistant Pseudomonas aeruginosa.

Giamarellou H, Zissis N, Tagari G, Bouzos J Antimicrob Agents Chemother. 1984; 25(4):534-6.

PMID: 6428310 PMC: 185575. DOI: 10.1128/AAC.25.4.534.

Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Carmine A, Brogden R, Heel R, Romankiewicz J, Speight T, Avery G Drugs. 1983; 26(4):279-333.

PMID: 6354685 DOI: 10.2165/00003495-198326040-00001.

In vitro and in vivo synergy between ceftriaxone and aminoglycosides against Pseudomonas aeruginosa.

Angehrn P Eur J Clin Microbiol. 1983; 2(5):489-95.

PMID: 6315424 DOI: 10.1007/BF02013914.

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