Susceptibility to Adjuvant Arthritis in DA and F344 Rats. A Dominant Trait Controlled by an Autosomal Gene Locus Linked to the Major Histocompatibility Complex

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1982 Oct 1

PMID 6215923

Citations 13

Authors

J R BATTISTO

R N Smith

K Beckman

M STERNLICHT

W L Welles

Affiliations

Soon will be listed here.

Abstract

The hereditary of adjuvant-induced arthritis in rats of the DA and Fisher 344 strains was examined. Development of arthritic lesions in response to a single injection of supplemented Freund's complete adjuvant has been found to be controlled by an autosomal, dominant gene locus, Ar. The capacity to respond was present in DA rats and absent in our Fisher rats. Ar has been found to be linked to the major histocompatibility complex genes with which it exhibits a high rate of recombination.

Citing Articles

Lung exposure of titanium dioxide nanoparticles induces innate immune activation and long-lasting lymphocyte response in the Dark Agouti rat.

Gustafsson A, Lindstedt E, Elfsmark L, Bucht A J Immunotoxicol. 2011; 8(2):111-21.

PMID: 21309687 PMC: 3104284. DOI: 10.3109/1547691X.2010.546382.

Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.

Lorentzen J, Glaser A, Jacobsson L, Galli J, Klareskog L, Luthman H Proc Natl Acad Sci U S A. 1998; 95(11):6383-7.

PMID: 9600974 PMC: 27729. DOI: 10.1073/pnas.95.11.6383.

Role of superantigens in experimental arthritis.

Abdelnour A, Zhao Y, Bremell T, Holmdahl R, Tarkowski A Springer Semin Immunopathol. 1996; 17(4):363-73.

PMID: 8966661 DOI: 10.1007/BF01795134.

Regulation of resistance against adjuvant arthritis in the Fisher rat.

van de Langerijt A, van Lent P, Hermus A, van de Putte L, van den Berg W Clin Exp Immunol. 1993; 94(1):150-5.

PMID: 8403498 PMC: 1534364. DOI: 10.1111/j.1365-2249.1993.tb05993.x.

Susceptibility to adjuvant arthritis: relative importance of adrenal activity and bacterial flora.

van de Langerijt A, van Lent P, Hermus A, Sweep C, Cools A, van den Berg W Clin Exp Immunol. 1994; 97(1):33-8.

PMID: 8033416 PMC: 1534789. DOI: 10.1111/j.1365-2249.1994.tb06575.x.