Hereditary Deficiency of OKT4-positive Cells: Studies for Mode of Inheritance and Lymphocyte Functions

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1984 Dec 1

PMID 6209207

Citations 2

Authors

T Fukuda

M Matsunaga

A Kurata

M Mine

N IKARI

S Katamine

H Kanazawa

K Eguchi

S Nagataki

Affiliations

Soon will be listed here.

Abstract

Two Graves' patients were found to have no OKT4+ cells in their peripheral blood lymphocytes (PBL). However, the reactivity of their lymphocytes with T4(T4A) and anti Leu-3a was normal and no autoantibodies to the OKT4 determinant were found in their sera. Cytofluorographic analysis of PBL from their family members showed three types of immunofluorescence profiles with OKT4. The first type was the complete OKT4+ cell deficiency, the second was the normal percentage of OKT4+ cells with half immunofluorescence intensity and the third was the normal staining pattern with OKT4. Phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) induced blastogenesis; PWM induced IgG synthesis, autologous and allogeneic mixed lymphocyte reaction, and Interleukin-2 (IL-2) production of their PBL were also normal. These results suggest that (i) the expression of determinant to OKT4 is transmitted as autosomal incomplete dominant trait and (ii) OKT4+ cell deficiency is not accompanied by a lack of the inducer/helper subset of T cells.

Citing Articles

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.

Becker K, Simon R, Bailey-Wilson J, Freidlin B, Biddison W, McFarland H Proc Natl Acad Sci U S A. 1998; 95(17):9979-84.

PMID: 9707586 PMC: 21447. DOI: 10.1073/pnas.95.17.9979.

Genetic variability of the human CD4 V2 domain.

Indraccolo S, Mion M, Biagiotti R, Romagnani S, Morfini M, Longo G Immunogenetics. 1996; 44(1):70-2.

PMID: 8613144 DOI: 10.1007/BF02602658.

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