A Third Rearranged and Expressed Gene in a Clone of Cytotoxic T Lymphocytes

Overview

Journal Nature

Specialty Science

Date 1984 Nov 1

PMID 6208487

Citations 141

Authors

H Saito

D M Kranz

Y Takagaki

A C Hayday

H N Eisen

S Tonegawa

Affiliations

Soon will be listed here.

Abstract

In addition to the two previously identified genes rearranged and expressed in a cytotoxic T-lymphocyte clone, we have identified a third gene that is also rearranged and expressed in the same clone. This new gene shows clonal diversity, codes for a polypeptide chain that contains immunoglobulin-like variable and constant domains, carries potential N-glycosylation sites and is a particularly attractive candidate for the gene that encodes the alpha-subunit of the heterodimeric antigen receptor of this T-cell clone.

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