Neutralizing Determinants Defined by Monoclonal Antibodies on Polypeptides Specified by Bovine Herpesvirus 1

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1984 Nov 1

PMID 6208375

Citations 20

Authors

J K Collins

A C Butcher

C A Riegel

V McGrane

C D Blair

Y A Teramoto

S Winston

Affiliations

Soon will be listed here.

Abstract

Monoclonal antibodies were used to study neutralizing determinants on polypeptides of bovine herpesvirus 1. Two of three monoclonal antibodies which recognized nonoverlapping epitopes on a glycoprotein of 82,000 daltons were found to neutralize. A second group of monoclonal antibodies that individually precipitated five viral glycopolypeptides ranging in size from 102,000 to 55,000 daltons also neutralized. Two monoclonal antibodies which were the most efficient in neutralization recognized a non-glycosylated protein of 115,000 daltons which was the major polypeptide on the virus. A fourth group of monoclonal antibodies precipitated a non-glycosylated polypeptide of 91,000 daltons and several smaller polypeptides, but these antibodies demonstrated only limited neutralizing activity.

Citing Articles

Neutralizing and complement-fixing monoclonal antibodies as an aid to the diagnosis of equine herpesvirus-1 infection.

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Production and characterization of bovine herpesvirus 1 glycoprotein B ectodomain derivatives in an hsp70A gene promoter-based expression system.

Li Y, van Drunen Littel-van den Hurk S, Liang X, Babiuk L Arch Virol. 1996; 141(10):2019-29.

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Identification of 108K, 93K, and 42K glycoproteins of bovine herpesvirus-1 by monoclonal antibodies.

Baranowski E, Dubuisson J, Pastoret P, Thiry E Arch Virol. 1993; 133(1-2):97-111.

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Monoclonal antibodies that distinguish between encephalitogenic bovine herpesvirus type 1.3 and respiratory bovine herpesvirus type 1.1.

Chung C, Pearson L, Ayers V, Collins J Clin Diagn Lab Immunol. 1994; 1(1):83-8.

PMID: 7496928 PMC: 368201. DOI: 10.1128/cdli.1.1.83-88.1994.

Reactivity of monoclonal antibodies to proteins of a neurotropic bovine herpesvirus 1 (BHV-1) strain and to proteins of representative BHV-1 strains.

Friedli K, Metzler A Arch Virol. 1987; 94(1-2):109-22.

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