Localization of the L1Md Family of Repeated Sequences in the Mouse Albumin-alpha-fetoprotein Gene Complex

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1984 Aug 24

PMID 6206473

Citations 2

Authors

R Cooper

C E Herzog

M L Li

W F Zapisek

P R Hoyt

H Ratrie 3rd

J Papaconstantinou

Affiliations

Soon will be listed here.

Abstract

Studies on the beta-globin gene complex in the mouse have demonstrated the existence of repeated DNA sequences interspersed throughout the intergenic regions (1,2). These sequences are members of families of middle repetitive sequences and have been mapped to specific intergenic sites in the 60 kbp beta-globin complex. In this study we present evidence that members of this middle repetitive family of DNA sequences, the L1Md family, are interspersed throughout the mouse albumin and alpha-fetoprotein gene complex. Unlike those of the beta-globin complex, all of which are found in the intergenic regions, these sequences are localized within intron 12 of the albumin gene and intron 3 of the AFP gene as well as twice in the 13.5 kbp intergenic region that links the albumin gene to the AFP gene.

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