Studies on B-cell Memory. III. T-dependent Aspect of B Memory Generation in Mice Immunized with T-independent Type-2(TI-2) Antigen

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1984 Sep 1

PMID 6205986

Citations 4

Authors

T Hosokawa

Y Tanaka

A AOIKE

K Kawai

S Muramatsu

Affiliations

Soon will be listed here.

Abstract

The time course of B-cell memory development to a dinitrophenyl (DNP) T-independent type-2 (TI-2) antigen was investigated by adoptive cell transfer. Strong IgM and IgG memory developed in BALB/c mice after immunization with DNP-dextran, to be recalled by challenge with either T-dependent (TD) antigen or TI-2 antigen. However, only weak IgM memory and very feeble IgG memory were detected in athymic nude mice receiving the same immunization as euthymic mice. Once memory was established under probable T cell influence, its recall by TI-2 antigen challenge seemed independent of T cell help and did not require sharing of carriers between priming and challenge antigens. The following may be concluded. (i) Long-term IgM and IgG memory is induced by TI-2 antigen priming in the presence of functional T cells. (ii) The class switch from IgM to IgG in the memory B cell pool is driven effectively by TI-2 antigen and is probably T cell-dependent.

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References

Mitchell G, Miller J . Immunological activity of thymus and thoracic-duct lymphocytes. Proc Natl Acad Sci U S A. 1968; 59(1):296-303. PMC: 286035. DOI: 10.1073/pnas.59.1.296. View

Claman H, Chaperon E, TRIPLETT R . Immunocompetence of transferred thymus-marrow cell combinations. J Immunol. 1966; 97(6):828-32. View

Baker P, STASHAK P, Amsbaugh D, PRESCOTT B . Characterization of the antibody response to type 3 pneumococcal polysaccharide at the cellular level. I. Dose-response studies and the effect of prior immunization on the magnitude of the antibody response. Immunology. 1971; 20(4):469-80. PMC: 1456005. View

Hosono M, Muramatsu S . Use of 2-mercaptoethanol for distinguishing between IgM and IgG antibody-producing cells of mice immunized with bovine globulin. J Immunol. 1972; 109(4):857-63. View

Del Guercio P, Thobie N, Poirier M . IgM anamnestic immune response to the haptenic determinant DNP on a thymus-independent carrier. J Immunol. 1974; 112(1):427-9. View

Andersson B, Blomgren H . T-cell response to polyvinyl pyrrolidone is linked to maturity of B cells. Nature. 1975; 253(5491):476-7. DOI: 10.1038/253476a0. View

Schrader J . The role of T cells in IgG production; thymus-dependent antigens induce B cell memory in the absence of T cells. J Immunol. 1975; 114(6):1665-9. View

Kataoka Y, Sado T . The radiosensitivity of T and B lymphocytes in mice. Immunology. 1975; 29(1):121-30. PMC: 1445853. View

Okumura K, Metzler C, Tsu T, Herzenberg L . Two stages of B-cell memory development with different T-cell requirements. J Exp Med. 1976; 144(2):345-57. PMC: 2190374. DOI: 10.1084/jem.144.2.345. View

10.

Diaz-Espada F, Bernabe R . Development of B cell subsets: effect of priming on in vitro TNP-LPS responsiveness. J Immunol. 1978; 121(1):13-8. View

11.

Schott C, Merchant B . Carrier-specific immune memory to a thymus-independent antigen in congenitally athymic mice. J Immunol. 1979; 122(5):1710-8. View

12.

Umetsu D, Thorbecke G . Cross-priming of murine B cells with TNP conjugates of hemocyanin and Ficoll: characteristics of primed B cells responding to both antigens. J Immunol. 1979; 123(1):396-404. View

13.

Hosokawa T, Amagai T, Muramatsu S . Studies on B-cell memory. I. Generation and exhaustion of B-cell memory by thymus-dependent antigen in T-cell depleted mice. Immunology. 1979; 38(2):283-9. PMC: 1457936. View

14.

Hosokawa T . Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory. Immunology. 1979; 38(2):291-9. PMC: 1457925. View

15.

Mongini P, STEIN K, Paul W . T cell regulation of IgG subclass antibody production in response to T-independent antigens. J Exp Med. 1981; 153(1):1-12. PMC: 2186053. DOI: 10.1084/jem.153.1.1. View

16.

Colle J, Motta I, Truffa-Bachi P . Generation of immune memory by haptenated derivatives of thymus-independent antigens in C57BL/6 mice. I. The differentiation of memory B lymphocytes into antibody-secreting cells depends on the nature of the thymus-independent carrier used for.... Cell Immunol. 1983; 75(1):52-62. DOI: 10.1016/0008-8749(83)90304-0. View

17.

Eisen H, Kern M, NEWTON W, Helmreich E . A study of the distribution of 2,4-dinitrobenzene sensitizers between isolated lymph node cells and extracellular medium in relation to induction of contact skin sensitivity. J Exp Med. 1959; 110(2):187-206. PMC: 2136994. DOI: 10.1084/jem.110.2.187. View

18.

RITTENBERG M, PRATT K . Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969; 132(2):575-81. DOI: 10.3181/00379727-132-34264. View