Life Span, Leukaemia and Amyloid Incidences of Untreated and Polycation-treated AKR Mice

Overview

Journal Br J Cancer

Specialty Oncology

Date 1978 Jan 1

PMID 619959

Citations 1

Authors

P Ebbesen

Affiliations

Soon will be listed here.

Abstract

AKR mice, which have a short mean survival time and usually die with leukaemia, were studied from one month of age for correlation between these two parameters. For untreated animals we found the same mean survival time whether or not leukaemia occurred. By treating sucklings with the polycations diethylaminoethyl-dextran or hexadimethrine bromide the leukaemia incidence was significantly reduced. However, the mean survival time was unchanged, and remained the same in leukaemic and non-leukaemic animals. It is therefore suggested that the early death of AKR mice results from an ageing process and does not require leukaemia for implementation. Our prophylactic polycation treatment was furthermore found to induce spleen amyloid in some but not all of the mice that remained non-leukaemic.

Citing Articles

Variations in erythropoiesis throughout a lifetime. Studies in a high-leukaemic mouse strain, the AKR/O strain, and a non-leukaemic strain, the WLO strain.

Hellebostad M, Sanengen T, Halvorsen S Blut. 1990; 61(6):358-63.

PMID: 2291984 DOI: 10.1007/BF01738550.

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