Influence of DEAE-dextran, Polybrene, Dextran and Dextran Sulphate on Spontaneous Leukaemia Development in AKR Mice and Virus Induced Leukaemia in BALB-c Mice

Overview

Journal Br J Cancer

Specialty Oncology

Date 1974 Jul 1

PMID 4413876

Citations 3

Authors

P Ebbesen

Affiliations

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Abstract

AKR mice of which more than 90% die of lymphatic thymus leukaemia, had their mean survival time increased by weekly intraperitoneal inoculation of either of the two polycations DEAE-dextran and polybrene. Administration of the neutral dextran had no effect, whereas the polyanion dextran sulphate accelerated leukaemia development.Adult BALB/c mice infected with Rauscher leukaemia virus and treated from the time of palpable spleen enlargement, showed a life prolonging effect of the polycations DEAE/dextran and polybrene, and of neutral dextran. BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.

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