Lanthanides Are Transported by Ionophore A23187 and Mimic Calcium in the Histamine Secretion Process

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1983 Oct 1

PMID 6197128

Citations 7

Authors

M Amellal

Y Landry

Affiliations

Soon will be listed here.

Abstract

Ionophore A23187 induced histamine release from peritoneal rat mast cells in the presence of lanthanum or terbium as it did in the presence of calcium. Low concentrations of lanthanides (10(-5) to 2 X 10(-4) M) were more efficient than similar concentrations of calcium. The effect of low concentrations of calcium and lanthanides were additive. Increasing the concentration of lanthanides above 10(-3) M decreased histamine release. This decrease was partly reversed by calcium. Calmodulin inhibitors, phenothiazines, R24571 and mepacrine, inhibited the histamine release induced by either calcium or lanthanides. Zn2+, a calmodulin inhibitor transported by A23187, inhibited more potently the calcium-dependent histamine release. Lanthanides decrease histamine release induced by 48/80 in the absence of added calcium. These data show that ionophore A23187 can transport lanthanides across the plasma membrane of mast cells, allowing the trivalent cations to substitute for calcium in the activation of calmodulin or calmoduline-like proteins.

Citing Articles

Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin.

Wang E, Taylor R, Pfeiffer D Biophys J. 1998; 75(3):1244-54.

PMID: 9726927 PMC: 1299800. DOI: 10.1016/S0006-3495(98)74044-5.

Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells.

Jaffar Z, Pearce F Agents Actions. 1993; 40(1-2):18-27.

PMID: 7511869 DOI: 10.1007/BF01976747.

Sodium-potassium ATPase inhibition potentiates compound 48/80-induced histamine secretion from mast cells.

Amellal M, Binck M, Frossard N, Ilien B, Landry Y Br J Pharmacol. 1984; 82(2):423-30.

PMID: 6203594 PMC: 1987041. DOI: 10.1111/j.1476-5381.1984.tb10777.x.

Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells.

Grosman N Agents Actions. 1986; 17(5-6):427-35.

PMID: 2422900 DOI: 10.1007/BF01965509.

Transmembrane sodium and potassium gradients modulate histamine secretion induced by ionophore A23187.

Amellal M, Bronner C, Landry Y Br J Pharmacol. 1985; 85(4):819-26.

PMID: 2412623 PMC: 1916652. DOI: 10.1111/j.1476-5381.1985.tb11080.x.

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