Site of Action of a Ribosomal RNA Methylase Responsible for Resistance to Erythromycin and Other Antibiotics

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1983 Oct 25

PMID 6195156

Citations 95

Authors

R Skinner

E Cundliffe

F J Schmidt

Affiliations

Soon will be listed here.

Abstract

The enzyme which confers resistance to erythromycin in the producing organism Streptomyces erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S rRNA. This corresponds to residue Ade 2058 in Escherichia coli 23 S RNA. The methylase responsible for resistance to macrolides, lincomycin, and streptogramin B-related antibiotics in Staphylococcus aureus also acts at this site.

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