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Translational Coupling During Expression of the Tryptophan Operon of Escherichia Coli

Overview
Journal Genetics
Publisher Oxford University Press
Specialty Genetics
Date 1980 Aug 1
PMID 6162715
Citations 182
Authors
D S Oppenheim
C Yanofsky
Affiliations
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Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

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