Regional 5-HT Analysis in Roman High- and Low-avoidance Rats Following MAO Inhibition

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1980 Dec 5

PMID 6162652

Citations 11

Authors

P Driscoll

J Dedek

J R Martin

K Baettig

Affiliations

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Abstract

5-HT and 5-HIAA levels were investigated in three brain regions of Roman high- and low-avoidance rats, following 10, 30 and 60 min of MAO inhibition (pargyline injection). Higher levels of 5-HT in the cortex at 30 and 60 min, as well as a higher disappearance rate of 5-HIAA in the midbrain/medulla region were exhibited by Roman high-avoidance rats, thus further characterizing the differences previously observed in whole brain 5-HT synthesis between these selected rat lines.

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