Substance P Increases Hypothalamic Blood Flow Via an Indirect Adrenergic-cholinergic Interaction

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1980 Jan 1

PMID 6162500

Citations 1

Authors

K P Klugman

F Lembeck

S Markowitz

G Mitchell

C Rosendorff

Affiliations

Soon will be listed here.

Abstract

1 Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. 2 Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. 3 Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. 4 Chemical sympathectomy of the hypothalamus with 6-hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. 5 Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. 6 These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP.

Citing Articles

Neuropeptide substance P improves water maze performance in aged rats.

Hasenohrl R, Huston J, Schuurman T Psychopharmacology (Berl). 1990; 101(1):23-6.

PMID: 1693002 DOI: 10.1007/BF02253712.

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