IgA-dependent, Monocyte-mediated, Antibacterial Activity

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1980 Aug 1

PMID 6156988

Citations 20

Authors

G H Lowell

L F SMITH

J M Griffiss

B L Brandt

Affiliations

Soon will be listed here.

Abstract

IgA purified from the sera of patients convalescing from disseminated group C meningococcal disease induced human monocyte-mediated anti-meningococcal activity in vitro in the absence of complement. Both IgA- and IgG-dependent activity were directed against the group C meningococcal polysaccharide (Csss) capsule. The amount of IgA that was effective bound less than 1 ng of Csss. Antibacterial activity was dependent upon the length and the temperature of the test incubation and on the concentration of monocytes. The implications of this mechanism for local cell-mediated antibacterial immunity are discussed.

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