Multivalent Translational Control of Transcription Termination at Attenuator of IlvGEDA Operon of Escherichia Coli K-12

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1980 Apr 1

PMID 6154938

Citations 76

Authors

R P Lawther

G W Hatfield

Affiliations

Soon will be listed here.

Abstract

The regulatory region for the ilvGEDA operon of Escherichia coli K-12 has been located and characterized. ilv leader RNA transcribed from this region is described, and the DNA sequence of the region is presented. This DNA sequence contains a transcription promoter, a region coding for a 32-amino-acid polypeptide containing multiple isoleucine, valine, and leucine codons, and a transcription termination site preceding the first structural gene. The mutually exclusive secondary structures of the leader RNA have been analyzed. On the basis of these data, a model for the multivalent attenuation of the ilvGEDA operon is proposed.

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