Bleomycin-induced Structural Chromosomal Aberrations in Spermatogonia and Bone-marrow Cells of Mice

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1980 Feb 1

PMID 6153758

Citations 6

Authors

P P Van Buul

J H Goudzwaard

Affiliations

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Abstract

The induction of structural chromosomal aberrations by bleomycin (BLM) was studied in bone-marrow cells and spermatogonia of the mouse at doses of 10, 20, 40 and 80 mg/kg. BLM induced genetically important reciprocal translocations in stem-cell spermatogonia as measured with the spermatocyte test, and the response of bone-marrow cells to BLM was not markedly different from that of spermatogonia.

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