Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy

Overview

Journal World J Mens Health

Date 2018 Dec 28

PMID 30588779

Citations 23

Authors

Keisuke Okada

Masato Fujisawa

Affiliations

Soon will be listed here.

Abstract

The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue. Fertile male patients who receive radiation and/or chemotherapy face temporary, long-term, or permanent gonadal damage, particularly with exposure to alkylating agents and whole-body irradiation, which sometimes induce critical germ cell damage. These cytotoxic treatments have a significant impact on a patient's ability to have their own biological offspring, which is of particular concern to cancer patients of reproductive age. Therefore, various strategies are needed in order to preserve male fertility. Sperm cryopreservation is an effective method for preserving spermatozoa. Advances have also been achieved in pre-pubertal germ cell storage and research to generate differentiated male germ cells from various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and spermatogonial stem cells. These approaches offer hope to many patients in whom germ cell loss is associated with sterility, but are still experimental and preliminary. This review examines the current understanding of the effects of chemotherapy and radiation on male fertility.

Citing Articles

Riluzole Reverses Blood-Testis Barrier Loss to Rescue Chemotherapy-Induced Male Infertility by Binding to TRPC.

Huang R, Xia H, Lin W, Wang Z, Li L, Deng J Cells. 2024; 13(23).

PMID: 39682764 PMC: 11640501. DOI: 10.3390/cells13232016.

An overview of different methods to establish a murine premature ovarian failure model.

Pouladvand N, Azarnia M, Zeinali H, Fathi R, Tavana S Animal Model Exp Med. 2024; 7(6):835-852.

PMID: 39219374 PMC: 11680483. DOI: 10.1002/ame2.12477.

Prostate radiotherapy may cause fertility issues: a retrospective analysis of testicular dose following modern radiotherapy techniques.

Kissel M, Terlizzi M, Giraud N, Alexis A, Cheve M, Vautier J Radiat Oncol. 2024; 19(1):101.

PMID: 39090684 PMC: 11293176. DOI: 10.1186/s13014-024-02498-3.

An Assessment of Cryopreserved Semen and Testicular Tissue Collected Before and After Cancer Treatment Initiation.

Fernandez-Gonzalez M, Radauer-Plank A, Borgmann-Staudt A, Geiger W, Goranova I, Klco-Brosius S Cancer Manag Res. 2024; 16:871-882.

PMID: 39077055 PMC: 11284135. DOI: 10.2147/CMAR.S460960.

Radiotherapy and Testicular Function: A Comprehensive Review of the Radiation-Induced Effects with an Emphasis on Spermatogenesis.

Georgakopoulos I, Kouloulias V, Ntoumas G, Desse D, Koukourakis I, Kougioumtzopoulou A Biomedicines. 2024; 12(7).

PMID: 39062064 PMC: 11274587. DOI: 10.3390/biomedicines12071492.

References

Howell S, Radford J, Ryder W, Shalet S . Testicular function after cytotoxic chemotherapy: evidence of Leydig cell insufficiency. J Clin Oncol. 1999; 17(5):1493-8. DOI: 10.1200/JCO.1999.17.5.1493. View

Thomson J, Itskovitz-Eldor J, Shapiro S, Waknitz M, Swiergiel J, Marshall V . Embryonic stem cell lines derived from human blastocysts. Science. 1998; 282(5391):1145-7. DOI: 10.1126/science.282.5391.1145. View

Generoso W, Witt K, Cain K, Hughes L, Cacheiro N, Lockhart A . Dominant lethal and heritable translocation tests with chlorambucil and melphalan in male mice. Mutat Res. 1995; 345(3-4):167-80. DOI: 10.1016/0165-1218(95)90052-7. View

Swerdlow A, Jacobs P, Marks A, Maher E, Young T, Barber J . Fertility, reproductive outcomes, and health of offspring, of patients treated for Hodgkin's disease: an investigation including chromosome examinations. Br J Cancer. 1996; 74(2):291-6. PMC: 2074565. DOI: 10.1038/bjc.1996.355. View

West F, Machacek D, Boyd N, Pandiyan K, Robbins K, Stice S . Enrichment and differentiation of human germ-like cells mediated by feeder cells and basic fibroblast growth factor signaling. Stem Cells. 2008; 26(11):2768-76. DOI: 10.1634/stemcells.2008-0124. View

Mydlo J, Lebed B . Does brachytherapy of the prostate affect sperm quality and/or fertility in younger men?. Scand J Urol Nephrol. 2004; 38(3):221-4. DOI: 10.1080/00365590410025451. View

Hermann B, Sukhwani M, Lin C, Sheng Y, Tomko J, Rodriguez M . Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. Stem Cells. 2007; 25(9):2330-8. PMC: 3593092. DOI: 10.1634/stemcells.2007-0143. View

Miller B, Adler I . Aneuploidy induction in mouse spermatocytes. Mutagenesis. 1992; 7(1):69-76. DOI: 10.1093/mutage/7.1.69. View

Pectasides D, Pectasides E, Papaxoinis G, Skondra M, Gerostathou M, Karageorgopoulou S . Testicular function in poor-risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy. J Androl. 2009; 30(3):280-6. DOI: 10.2164/jandrol.108.006437. View

10.

Hodgson D, Pintilie M, Gitterman L, Dewitt B, Buckley C, Ahmed S . Fertility among female hodgkin lymphoma survivors attempting pregnancy following ABVD chemotherapy. Hematol Oncol. 2006; 25(1):11-5. DOI: 10.1002/hon.802. View

11.

Bahadur G, Ralph D . Gonadal tissue cryopreservation in boys with paediatric cancers. Hum Reprod. 1999; 14(1):11-7. DOI: 10.1093/humrep/14.1.11. View

12.

Lu C, Meistrich M . Cytotoxic effects of chemotherapeutic drugs on mouse testis cells. Cancer Res. 1979; 39(9):3575-82. View

13.

Howell S, Shalet S . Spermatogenesis after cancer treatment: damage and recovery. J Natl Cancer Inst Monogr. 2005; (34):12-7. DOI: 10.1093/jncimonographs/lgi003. View

14.

Jacob A, Barker H, Goodman A, Holmes J . Recovery of spermatogenesis following bone marrow transplantation. Bone Marrow Transplant. 1998; 22(3):277-9. DOI: 10.1038/sj.bmt.1701332. View

15.

Chiba K, Fujisawa M . Fertility preservation in men with cancer. Reprod Med Biol. 2018; 13(4):177-184. PMC: 5892996. DOI: 10.1007/s12522-014-0180-6. View

16.

Clifton D, Bremner W . The effect of testicular x-irradiation on spermatogenesis in man. A comparison with the mouse. J Androl. 1983; 4(6):387-92. DOI: 10.1002/j.1939-4640.1983.tb00765.x. View

17.

Koumarianou A, Xiros N, Papageorgiou E, Pectasides D, Economopoulos T . Survival improvement of young patients, aged 16-23, with Hodgkin lymphoma (HL) during the last three decades. Anticancer Res. 2007; 27(2):1191-7. View

18.

BUCHANAN J, Fairley K, BARRIE J . Return of spermatogenesis after stopping cyclophosphamide therapy. Lancet. 1975; 2(7926):156-7. DOI: 10.1016/s0140-6736(75)90059-8. View

19.

Landis S, Murray T, Bolden S, Wingo P . Cancer statistics, 1999. CA Cancer J Clin. 1999; 49(1):8-31, 1. DOI: 10.3322/canjclin.49.1.8. View

20.

Yang S, Bo J, Hu H, Guo X, Tian R, Sun C . Derivation of male germ cells from induced pluripotent stem cells in vitro and in reconstituted seminiferous tubules. Cell Prolif. 2012; 45(2):91-100. PMC: 6496715. DOI: 10.1111/j.1365-2184.2012.00811.x. View