Immunohistochemical Study of Pheochromocytomas. An Investigation of Methionine-enkephalin, Vasoactive Intestinal Peptide, Somatostatin, Corticotropin, Beta-endorphin, and Calcitonin in 16 Tumors

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1984 Jan 1

PMID 6140850

Citations 14

Authors

J Hassoun

G Monges

P Giraud

J F Henry

C Charpin

H PAYAN

M TOGA

Affiliations

Soon will be listed here.

Abstract

Immunohistochemical investigations were carried out on 16 pheochromocytomas for a study of their immunoreactivity to methionine-enkephalin, vasoactive intestinal peptide, somatostatin, corticotropin, beta-endorphin, and calcitonin on serial semithin araldite sections. All antiserums except anti-beta-endorphin, selectively stained a variable number of distinct tumor cells. Methionine-enkephalin-immunoreactive cells were the most frequent. The neuropeptide content of pheochromocytomas appears highly diverse and unpredictable. These findings are supportive of the concept of multisecretory APUD cells of neural crest origin and rule out any of these neuropeptides as reliable immunohistochemical markers for tumor chromaffin cells.

Citing Articles

Vasoactive Intestinal Peptide-Secreting Pheochromocytoma: A Case Report and Review of Literature.

Yee S, Meyer J, Wong L AACE Clin Case Rep. 2022; 8(4):158-162.

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When a Multidisciplinary Approach Is Life-Saving: A Case Report of Cardiogenic Shock Induced by a Large Pheochromocytoma.

Baio R, Pagano T, Molisso G, Di Mauro U, Intilla O, Albano F Diseases. 2022; 10(2).

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A retroperitoneal sympathetic paraganglioma invading the duodenum and mimicking a submucosal tumor.

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Assessment of adrenal surgery on creatinine clearance in patients with phaeochromocytoma.

Nakada T, Kaneko H, Kubota Y, Watanabe M, Sasagawa I, Yagisawa T Int Urol Nephrol. 1995; 27(2):121-30.

PMID: 7591566 DOI: 10.1007/BF02551307.

Endocrine cells producing regulatory peptides.

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