Pancreatic Islet Cell Carcinoma Producing Gastrin, ACTH, Alpha-endorphin, Somatostatin and Calcitonin

Overview

Journal Am J Gastroenterol

Specialty Gastroenterology

Date 1980 Jul 1

PMID 6107042

Citations 15

Authors

S L Asa

K Kovacs

D W Killinger

N Marcon

M PLATTS

Affiliations

Soon will be listed here.

Abstract

An islet cell carcinoma of the pancreas is described in a 68-year old woman which clinically produced Zollinger-Ellison syndrome and, later in its course, Cushing syndrome. The tumor was found to contain gastrin, ACTH, alpha-endorphin, somatostatin and calcitonin, by the immunoperoxidase technic. Electron microscopy revealed a single tumor cell type containing secretory granules of variable size, morphology and electron density. It appears that a single tumor cell population produced all five hormones and caused a transition in clinical symptomatology, while undergoing no change in morphology.

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