Carbachol Can Be Released at a Cholinergic Ganglionic Synapse As a False Transmitter

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1983 Aug 1

PMID 6136041

Citations 5

Authors

G Baux

L Tauc

Affiliations

Soon will be listed here.

Abstract

Carbachol was injected into a presynaptic cholinergic neuron in the buccal ganglion of Aplysia and the quantal aspects of the Cl- -dependent postsynaptic response to a prolonged stimulation were analyzed by a statistical fluctuation method. The calculated amplitude of the miniature postsynaptic current was increased with respect to control. Statistical fluctuation analysis was also used to analyze the postsynaptic response obtained during ionophoretic application of acetylcholine and carbachol. The calculated unitary channel current was found to be greater for carbachol than for acetylcholine. This increase could explain the larger miniature postsynaptic current seen after intracellular injection of carbachol into the presynaptic neuron if carbachol was released at the synapse as a false transmitter. This conclusion was supported by the observation that it was possible to restore transmission at a synapse previously blocked by presynaptic intracellular injection of acetylcholinesterase with a presynaptic injection of carbachol.

Citing Articles

Presynaptic actions of curare and atropine on quantal acetylcholine release at a central synapse of Aplysia.

Baux G, Tauc L J Physiol. 1987; 388:665-80.

PMID: 3656203 PMC: 1192571. DOI: 10.1113/jphysiol.1987.sp016637.

Presynaptic transmitter content controls the number of quanta released at a neuro-neuronal cholinergic synapse.

Poulain B, Baux G, Tauc L Proc Natl Acad Sci U S A. 1986; 83(1):170-3.

PMID: 3510429 PMC: 322813. DOI: 10.1073/pnas.83.1.170.

Quantal analysis of action of hemicholinium-3 studied at a central cholinergic synapse of Aplysia.

Baux G, Poulain B, Tauc L J Physiol. 1986; 380:209-26.

PMID: 3039124 PMC: 1182933. DOI: 10.1113/jphysiol.1986.sp016281.

Both presynaptic nicotinic-like and muscarinic-like autoreceptors regulate acetylcholine release at an identified neuro-neuronal synapse of Aplysia.

Fossier P, Poulain B, Baux G, Tauc L Pflugers Arch. 1988; 411(4):345-52.

PMID: 2899868 DOI: 10.1007/BF00587712.

Receptor-mediated presynaptic facilitation of quantal release of acetylcholine induced by pralidoxime in Aplysia.

Fossier P, Baux G, Poulain B, Tauc L Cell Mol Neurobiol. 1990; 10(3):383-404.

PMID: 2253262 PMC: 11567356. DOI: 10.1007/BF00711182.

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