Changes in the Mechanisms of Hormone and Neurotransmitter Action During Aging: Current Status of the Role of Receptor and Post-receptor Alterations. A Review

Alterations in responsiveness to hormones and neurotransmitters during aging appear to be due to changes at both the receptor and post-receptor levels. Although many such observations have now been independently confirmed, disagreement over the extent and/or importance of receptor alterations exists in a number of cases. Receptors do not appear to change with age in certain systems, but only a few reports have actually been able to localize particular post-receptor alterations responsible for changes in response. This review attempts to catalogue studies in these areas which have been carried out to date, and discusses possible reasons for discrepancies as well as future research directions.