An Overview of the Genetics of Psychopathology

Overview

Journal Behav Genet

Date 1982 Feb 1

PMID 6124234

Authors

D R Petersen

A C Collins

R G Miles

Affiliations

Soon will be listed here.

Abstract

The suggestion that psychopathologies are in part mediated by aberrant catecholamine metabolism has resulted in one of the more rapidly growing areas of pharmacogenetics. Collectively, the studies conducted to date indicate that psychopathological conditions have multiple causes which cannot be related to single genetic or biochemical deficits. However, through multidisciplinary research integrating behavioral, genetic, and biochemical approaches, a great deal of insight may be gained concerning the causes of psychopathological disorders and the use of drug therapy to modify the course of these illnesses.

References

Pandey G, Dorus E, Shaughnessy R, Davis J . Genetic control of platelet monoamine oxidase activity: studies on normal families. Life Sci. 1979; 25(13):1173-8. DOI: 10.1016/0024-3205(79)90140-1. View

Wyatt R, Potkin S, Murphy D . Platelet monoamine oxidase activity in schizophrenia: a review of the data. Am J Psychiatry. 1979; 136(4A):377-85. View

Kessler S, Ciaranello R, Shire J, Barchas J . Genetic variation in activity of enzymes involved in synthesis of catecholamines. Proc Natl Acad Sci U S A. 1972; 69(9):2448-50. PMC: 426962. DOI: 10.1073/pnas.69.9.2448. View

Stolk J, Hurst J, Van Riper D, Harris P . Genetic analysis of serum dopamine-beta-hydroxylase activity in rats. Mol Pharmacol. 1979; 16(3):922-31. View

Nies A, Robinson D, Lamborn K, Lampert R . Genetic control of platelet and plasma monoamine oxidase activity. Arch Gen Psychiatry. 1973; 28(6):834-8. DOI: 10.1001/archpsyc.1973.01750360060008. View

Ciaranello R, Hoffman H, Shire J, Axelrod J . Genetic regulation of the catecholamine biosynthetic enzymes. II. Inheritance of tyrosine hydroxylase, dopamine-beta-hydroxylase, and phenylethanolamine N-methyltransferase. J Biol Chem. 1974; 249(14):4528-36. View

Baker H, Joh T, Reis D . Genetic control of number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum. Proc Natl Acad Sci U S A. 1980; 77(7):4369-73. PMC: 349836. DOI: 10.1073/pnas.77.7.4369. View

Wyatt R, Murphy D, Belmaker R, Cohen S, Donnelly C, Pollin W . Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Science. 1973; 179(4076):916-8. DOI: 10.1126/science.179.4076.916. View

Ciaranello R, Barchas R, Kessler S, Barchas J . Catecholamines: strain differences in biosynthetic enzyme activity in mice. Life Sci I. 1972; 11(12):565-72. DOI: 10.1016/0024-3205(72)90191-9. View

10.

Tunnicliff G, WIMER C, WIMER R . Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice. Brain Res. 1973; 61:428-34. DOI: 10.1016/0006-8993(73)90551-9. View

11.

Ciaranello R . Regulation of phenylethanolamine N-methyltransferase. Biochem Pharmacol. 1978; 27(15):1895-7. DOI: 10.1016/0006-2952(78)90002-3. View

12.

BELLIN J, Sorrentino J . Kinetic characteristics of monoamine oxidase and serum cholinesterase in several related rat strains. Biochem Genet. 1974; 11(4):309-17. DOI: 10.1007/BF00485998. View