[New Developments Concerning the Neuron Cell Membrane: Advances in the Structural Analysis of Transmembrane Ion Channels]

Overview

Journal Naturwissenschaften

Specialty Science

Date 1984 Jul 1

PMID 6090956

Citations 1

Authors

H Betz

Affiliations

Soon will be listed here.

Abstract

Information processing in the brain requires the activation of electrically and chemically gated ion channels in the neuronal plasma membrane. Recently, the function and the molecular composition of some of these membrane proteins have become the subject of extensive biochemical and biophysical analysis. From the currently available data, it is proposed that the architecture of different neuronal ion channels obeys common structural principles which may have resulted from a divergent evolution of a limited number of ancestor transmembrane polypeptides.

Citing Articles

Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.

Pfeiffer F, Simler R, Grenningloh G, Betz H Proc Natl Acad Sci U S A. 1984; 81(22):7224-7.

PMID: 6095276 PMC: 392111. DOI: 10.1073/pnas.81.22.7224.

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