The Dynamics of Mast Cell Secretion Mediated by IgE or Polyamines

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1984 Dec 1

PMID 6085217

Citations 4

Authors

G Berlin

Affiliations

Soon will be listed here.

Abstract

Mast cell secretion can be mediated not only by IgE but also by a number of secretagogues of various chemical structure. In the present study the dynamics of the mast cell secretory process induced by different polyamines and anti-IgE were compared using a combination of vital berberine binding (demonstrating intracellular granules that have released amines) and measurement of histamine and heparin release. The results suggest that the basic secretory pattern is the same no matter whether the secretion is induced by polymyxin B, polylysine, compound 48/80, or an IgE-anti-IgE reaction. Histamine can be released from intracellular granules which, according to previous results, may be reincorporated into the cytoplasm, but which are to a large extent expelled from the cell by exocytosis.

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References

Berlin G, Enerback L . Changes in numbers and heparin content of peritoneal fluid mast cells of growing rats measured by flow cytofluorometry. J Histochem Cytochem. 1978; 26(1):14-21. DOI: 10.1177/26.1.621375. View

Ennis M, Pearce F, WESTON P . Some studies on the release of histamine from mast cells stimulated with polylysine. Br J Pharmacol. 1980; 70(2):329-34. PMC: 2044337. DOI: 10.1111/j.1476-5381.1980.tb07940.x. View

Tizard I, HOLMES W . Degranulation of sensitised rat peritoneal mast cells in response to antigen, compound 48-80 and polymyxin B. A scanning electron microscope study. Int Arch Allergy Appl Immunol. 1974; 46(6):867-79. DOI: 10.1159/000231189. View

Enerback L . Berberine sulphate binding to mast cell polyanions: a cytofluorometric method for the quantitation of heparin. Histochemistry. 1974; 42(4):301-13. DOI: 10.1007/BF00492678. View

BLOOM G, Haegermark O . A study on morphological changes and histamine release induced by compound 48/80 in rat peritoneal mast cells. Exp Cell Res. 1965; 40(3):637-54. DOI: 10.1016/0014-4827(65)90241-7. View

Anderson P, Slorach S, UVNAS B . Sequential exocytosis of storage granules during antigen-induced histamine release from sensitized rat mast cells in vitro. An electron microscopic study. Acta Physiol Scand. 1973; 88(3):359-72. DOI: 10.1111/j.1748-1716.1973.tb05465.x. View

Hino R, Lau C, READ G . The site of action of the histamine releaser compound 45/80 in causing mast cell degranulation. J Pharmacol Exp Ther. 1977; 200(3):658-63. View

Lagunoff D . The mechanism of histamine release from mast cells. Biochem Pharmacol. 1972; 21(14):1889-96. DOI: 10.1016/0006-2952(72)90001-9. View

Carlsson S, Ritzen M . Mast cells and 5-HT. Intracellular release of 5-hydroxytryptamine (5-HT) from storage granules during anaphylaxis or treatment with compound 48-80. Acta Physiol Scand. 1969; 77(4):449-64. DOI: 10.1111/j.1748-1716.1969.tb04589.x. View

10.

Foreman J, Hallett M, MONGAR J . The relationship between histamine secretion and 45calcium uptake by mast cells. J Physiol. 1977; 271(1):193-214. PMC: 1353613. DOI: 10.1113/jphysiol.1977.sp011996. View

11.

Berlin G, Enerback L . Mast cell secretion. Rapid sealing of exocytotic cavities demonstrated by cytofluorometry. Int Arch Allergy Appl Immunol. 1984; 73(3):256-62. View

12.

Padawer J . The reaction of rat mast cells to polylysine. J Cell Biol. 2009; 47(2):352-72. PMC: 2108087. DOI: 10.1083/jcb.47.2.352. View

13.

Lagunoff D, Martin T, Read G . Agents that release histamine from mast cells. Annu Rev Pharmacol Toxicol. 1983; 23:331-51. DOI: 10.1146/annurev.pa.23.040183.001555. View

14.

Rohlich P, Anderson P, UVNAS B . Electron microscope observations on compounds 48-80-induced degranulation in rat mast cells. Evidence for sequential exocytosis of storage granules. J Cell Biol. 1971; 51(21):465-83. PMC: 2108143. DOI: 10.1083/jcb.51.2.465. View

15.

Enerback L, Svensson I . Isolation of rat peritoneal mast cells by centrifugation on density gradients of Percoll. J Immunol Methods. 1980; 39(1-2):135-45. DOI: 10.1016/0022-1759(80)90302-6. View

16.

Goth A, Adams H, KNOOHUIZEN M . Phosphatidylserine: selective enhancer of histamine release. Science. 1971; 173(4001):1034-5. DOI: 10.1126/science.173.4001.1034. View

17.

BLOOM G, Fredholm B, Haegermark O . Studies on the time course of histamine release and morphological changes induced by histamine liberators in rat peritoneal mast cells. Acta Physiol Scand. 1967; 71(4):270-82. DOI: 10.1111/j.1748-1716.1967.tb03734.x. View

18.

Shore P, BURKHALTER A, COHN Jr V . A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959; 127:182-6. View

19.

Enerback L, Berlin G, Svensson I, Rundquist I . Quantitation of mast cell heparin by flow cytofluorometry. J Histochem Cytochem. 1976; 24(12):1231-8. DOI: 10.1177/24.12.63510. View

20.

Morrison D . Receptor modulation and mast cell secretion. J Invest Dermatol. 1978; 71(1):85-91. DOI: 10.1111/1523-1747.ep12544433. View