Alpha 2.0
Login Register
» Articles » PMID: 6027082

Two Sites of Bile Formation As Determined by Mannitol and Erythritol Clearance in the Guinea Pig

Overview
Journal J Clin Invest
Specialty General Medicine
Date 1967 Jul 1
PMID 6027082
Citations 44
Authors
E L FORKER
Affiliations
Soon will be listed here.
Abstract

If water and inert solutes are assumed to pass from blood to bile through a fixed population of membrane pores, the changes in clearance produced by dehydrocholate suggest that osmotic filtration rather than diffusion is the predominant mode of transfer for mannitol and erythritol. Bile produced in the canaliculi is modified in the interlobular ducts by the action of secretin. If distal fluid transfer is an important determinant of the choleresis evoked by dehydrocholate, the mechanism appears to effect a net secretion or reabsorption of fluid at a rate roughly proportional to the rate of flow in the canaliculi.

Citing Articles

Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches.

Yaman Y, Kisi Y, Sengul S, Yildirim Y, Bay V Sci Rep. 2024; 14(1):13072.

PMID: 38844604 PMC: 11156902. DOI: 10.1038/s41598-024-64093-6.

Engineering Escherichia coli to Utilize Erythritol as Sole Carbon Source.

Ba F, Ji X, Huang S, Zhang Y, Liu W, Liu Y Adv Sci (Weinh). 2023; 10(14):e2207008.

PMID: 36938858 PMC: 10190533. DOI: 10.1002/advs.202207008.

A history of research into the physiology of bile, from Hippocrates to molecular medicine.

Erlinger S Clin Liver Dis (Hoboken). 2022; 20(Suppl 1):33-44.

PMID: 36518787 PMC: 9742757. DOI: 10.1002/cld.1266.

Pancreatic Leaks and Fistulae: An Endoscopy-Oriented Classification.

Mutignani M, Dokas S, Tringali A, Forti E, Pugliese F, Cintolo M Dig Dis Sci. 2017; 62(10):2648-2657.

PMID: 28780610 DOI: 10.1007/s10620-017-4697-5.

Physiology of bile secretion.

Esteller A World J Gastroenterol. 2008; 14(37):5641-9.

PMID: 18837079 PMC: 2748197. DOI: 10.3748/wjg.14.5641.

References
1.
Wheeler H . Role of bile ducts during secretin choleresis in dogs. Am J Physiol. 1966; 210(5):1153-9. DOI: 10.1152/ajplegacy.1966.210.5.1153. View
2.
FORKER E, Hogben C . Diodrast transit time in guinea pig biliary tree. Am J Physiol. 1967; 212(1):104-12. DOI: 10.1152/ajplegacy.1967.212.1.104. View
3.
CHENDEROVITCH J, PHOCAS E, RAUTUREAU M . Effects of hypertonic solutions on bile formation. Am J Physiol. 1963; 205(5):863-7. DOI: 10.1152/ajplegacy.1963.205.5.863. View
4.
Cook D, LAWLER C, CALVIN L, Green D . Mechanisms of bile formation. Am J Physiol. 1952; 171(1):62-74. DOI: 10.1152/ajplegacy.1952.171.1.62. View
5.
McCORKINDALE J, EDSON N . Polyol dehydrogenases. I. The specificity of rat-liver polyol dehydrogenase. Biochem J. 1954; 57(3):518-23. PMC: 1269791. DOI: 10.1042/bj0570518. View